取代二茂铁化合物的毒理学评价

Toxicological evaluation of substituted dicyclopentadienyliron (ferrocene) compounds.

作者信息

Leung H W, Hallesy D W, Shott L D, Murray F J, Paustenbach D J

出版信息

Toxicol Lett. 1987 Sep;38(1-2):103-8. doi: 10.1016/0378-4274(87)90117-2.

Abstract

The acute toxicity of 3 substituted ferrocenes: acetylferrocene, ethylferrocene, and 2,2-bis(ethylferrocenyl)propane (Catocene) were studied in rats, rabbits and monkeys. Acetylferrocene was found to be the most toxic. The oral lethal dose was less than 5 mg/kg for female rats, between 5 and 50 mg/kg for male rats, and between 10 and 100 mg/kg for monkeys. The toxicity of acetylferrocene appeared to be delayed, with most mortality occurring on the third day after dosing. Acetylferrocene was also highly toxic by skin or eye exposure. Gross pathological examination revealed signs of pneumonopathy in both the rats and monkeys. The mechanism by which monkeys are less susceptible than rats to the toxicity of acetylferrocene is not clear.

摘要

研究了3种取代二茂铁：乙酰基二茂铁、乙基二茂铁和2,2 - 双（乙基二茂铁基）丙烷（卡托辛）在大鼠、兔子和猴子中的急性毒性。发现乙酰基二茂铁毒性最大。雌性大鼠经口致死剂量小于5mg/kg，雄性大鼠为5至50mg/kg，猴子为10至100mg/kg。乙酰基二茂铁的毒性似乎具有延迟性，大多数死亡发生在给药后第三天。乙酰基二茂铁经皮肤或眼睛接触也具有高毒性。大体病理检查显示大鼠和猴子均有肺病迹象。猴子比大鼠对乙酰基二茂铁毒性更不敏感的机制尚不清楚。