Sarkar Shamim, Okafor Chika C
Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
Microorganisms. 2022 Oct 14;10(10):2031. doi: 10.3390/microorganisms10102031.
The presence of antibiotic residues in the tissue of food animals is a growing concern due to the adverse health effects that they can cause in humans, such as antibiotic resistance bacteria. An inspector-generated sampling (IGS) dataset from the United States National Residue Surveillance Program, collected between 2014 and 2019, was analyzed to investigate the association of changes in the veterinary feed directive (VFD) regulations on the detection of violative penicillin, tetracycline, sulfonamide, desfuroylceftiofur, tilmicosin, and florfenicol, residues in the tissue of food animals. Multivariable logistic regression models were used for analysis. While the animal production class was significantly associated with residue violations for tetracycline, having a sample collection date after the implementation of change in VFD regulations was not. However, the odds of detecting violative sulfonamide and penicillin residues in the tissue of food animals following the implementation of the change in VFD regulations were 36% and 24% lower than those collected before the implementation of the change in VFD regulations period, respectively, irrespective of animal production class. Violative desfuroylceftiofur, tilmicosin, and florfenicol residues in the tissue of food animals were not significantly associated with the implementation of changes in the VFD regulations. Further investigation of the factors that influence the presence of violative antibiotic residues in the tissue of food animals following the change in VFD regulations would lend clarity to this critical issue.
食用动物组织中存在抗生素残留，这一问题日益受到关注，因为它们会对人类健康造成不利影响，比如产生抗生素耐药菌。分析了2014年至2019年期间从美国国家残留监测计划中获取的检查员生成的抽样（IGS）数据集，以调查兽医饲料指令（VFD）法规的变化与食用动物组织中违规青霉素、四环素、磺胺类药物、脱呋喃甲酰头孢噻呋、替米考星和氟苯尼考残留检测之间的关联。使用多变量逻辑回归模型进行分析。虽然动物生产类别与四环素残留违规显著相关，但样本采集日期在VFD法规变更实施之后的情况并非如此。然而，无论动物生产类别如何，在VFD法规变更实施之后，食用动物组织中检测到违规磺胺类药物和青霉素残留的几率分别比在VFD法规变更实施之前采集的样本低36%和24%。食用动物组织中违规的脱呋喃甲酰头孢噻呋、替米考星和氟苯尼考残留与VFD法规的变更实施没有显著关联。进一步调查VFD法规变更后影响食用动物组织中违规抗生素残留存在的因素，将有助于阐明这一关键问题。
