高立体选择性合成脯氨酸衍生物。
Diastereoselective Synthesis of Highly Functionalized Proline Derivatives.
机构信息
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov str. 28/1, 119334 Moscow, Russia.
N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky Prosp., 119071 Moscow, Russia.
出版信息
Molecules. 2022 Oct 14;27(20):6898. doi: 10.3390/molecules27206898.
An efficient way to access highly functionalized proline derivatives was developed based on a Cu(I)-catalyzed reaction between CF-substituted allenynes and tosylazide, which involved a cascade of [3 + 2]-cycloaddition/ketenimine and a rearrangement/Alder-ene cyclization to afford the new proline framework with a high diastereoselectivity.
基于 Cu(I)催化的 CF 取代的allenynes 与对甲苯磺酰叠氮的反应，开发了一种高效获取高官能化脯氨酸衍生物的方法，该方法涉及[3 + 2]-环加成/亚胺和重排/Alder-ene 环化的级联反应，以高非对映选择性得到新的脯氨酸骨架。
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