Horn S, Mazor D, Zmora E, Meyerstein N
Transfusion. 1987 Sep-Oct;27(5):411-4. doi: 10.1046/j.1537-2995.1987.27587320535.x.
Fetal red cells are well suited for intrauterine life; however, little is known about their response to postnatal environments. The purpose of this work was to investigate the metabolic and membrane changes affecting newborn red cells during their exposure to storage in citrate-phosphate-dextrose (CPD) and citrate-phosphate-dextrose-adenine (CPDA-1). The findings suggest that newborn red cells are affected more by storage than are adult cells. These accelerated storage changes in the red cells of newborns may be related indirectly to the rapid adenosine triphosphate (ATP) decline. As is the case with adult red cells, fetal cells withstand storage in CPDA-1 better than in CPD. The storage lesion in these cells was partly reversible, as in adult cells, by incubation with adenosine. It was therefore concluded that newborn red cells obtained from placentas and stored for several weeks in CPD or CPDA-1 media or other media that improve the metabolic profile of these cells may be acceptable for transfusion.
胎儿红细胞非常适合子宫内的生活；然而，对于它们对出生后环境的反应却知之甚少。这项工作的目的是研究在柠檬酸盐-磷酸盐-葡萄糖（CPD）和柠檬酸盐-磷酸盐-葡萄糖-腺嘌呤（CPDA-1）中储存期间影响新生儿红细胞的代谢和膜变化。研究结果表明，新生儿红细胞比成人细胞更容易受到储存的影响。新生儿红细胞中这些加速的储存变化可能与三磷酸腺苷（ATP）的快速下降间接相关。与成人红细胞一样，胎儿细胞在CPDA-1中比在CPD中更能耐受储存。与成人细胞一样，这些细胞中的储存损伤部分可通过与腺苷孵育而逆转。因此得出结论，从胎盘获得并在CPD或CPDA-1培养基或其他改善这些细胞代谢特征的培养基中储存数周的新生儿红细胞可能可用于输血。
