Yan Bingdong, Cheng Zike, Lai Caiyan, Qiao Bin, Yuan Run, Zhang Chide, Pei Hua, Tu Jinchun, Wu Qiang
State Key Laboratory of Marine Resource Utilization in South China Sea, School of Materials Science and Engineering, Hainan University, Haikou 570228, China.
Department of Clinical Laboratory of the Second Affiliated Hospital, School of Tropical Medicine, Key Laboratory of Emergency and Trauma of Ministry of Education, Research Unit of Island Emergency Medicine, Chinese Academy of Medical Sciences (No. 2019RU013), Hainan Medical University, Haikou 571199, China.
Nanomaterials (Basel). 2022 Oct 11;12(20):3557. doi: 10.3390/nano12203557.
The electrodes of two-dimensional (2D) titanium dioxide (TiO) nanosheet arrays were successfully fabricated for microRNA-155 detection. The (001) highly active crystal face was exposed to catalyze signaling molecules ascorbic acid (AA). Zero-dimensional (0D) titanium carbide quantum dots (TiCT QDs) were modified to the electrode as co-catalysts and reduced the recombination rate of the charge carriers. Spectroscopic methods were used to determine the band structure of TiO and TiCT QDs, showing that a type Ⅱ heterojunction was built between TiO and TiCT QDs. Benefiting the advantages of materials, the sensing platform achieved excellent detection performance with a wide liner range, from 0.1 pM to 10 nM, and a low limit of detection of 25 fM (S/N = 3).
成功制备了用于检测微小RNA-155的二维（2D）二氧化钛（TiO₂）纳米片阵列电极。暴露（001）高活性晶面以催化信号分子抗坏血酸（AA）。将零维（0D）碳化钛量子点（Ti₃C₂Tₓ QDs）作为共催化剂修饰到电极上，降低了电荷载流子的复合率。采用光谱方法测定了TiO₂和Ti₃C₂Tₓ QDs的能带结构，表明在TiO₂和Ti₃C₂Tₓ QDs之间构建了Ⅱ型异质结。得益于材料的优势，该传感平台实现了优异的检测性能，线性范围宽，从0.1 pM到10 nM，检测下限低至25 fM（S/N = 3）。
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