Cerquido Ana Sofia, Vojtek Martin, Ribeiro-Oliveira Rita, Viegas Olga, Sousa Joana Beatriz, Ferreira Isabel M P L V O, Diniz Carmen
LAQV/REQUIMTE, Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
LAQV/REQUIMTE, Laboratory of Bromatology and Hydrology, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Pharmaceuticals (Basel). 2022 Oct 8;15(10):1231. doi: 10.3390/ph15101231.
(C.) belongs to the family Ericaceae and can be found in the Iberian Peninsula, especially on the coastal areas facing the Atlantic coast. berries have been used for centuries in traditional medicine. Recent studies have revealed that not only the berries but also the leaves have relevant antioxidant, antiproliferative, and anti-inflammatory properties, bringing this plant to the forefront of discussion. A systematic review of the literature was carried out to summarize the phenolic compounds and bioactive properties identified in berries and leaves and to search for research gaps on this topic. The search was conducted in three electronic databases (PubMed, SCOPUS, and Web of Science) using PRISMA methodology. The inclusion criteria were the chemical compositions of the berries, leaves, or their extracts and their bioactive properties. The exclusion criteria were agronomic and archaeological research. The number of studies concerning phenolic compounds' composition and the bioactive properties of berries and leaves is still limited (11 articles). However, the variety of polyphenolic compounds identified make it possible to infer new insights into their putative mechanism of action towards the suppression of NF-kB transcription factor activation, the modulation of inflammatory mediators/enzymes, the induction of apoptosis, the modulation of mitogen activated protein kinase, cell cycle arrest, and the reduction of oxidative stress. These factors can be of major relevance concerning the future use of as nutraceuticals, food supplements, or medicines. Nevertheless, more scientific evidence concerning bioactivity is required.
（C.）属于杜鹃花科，生长于伊比利亚半岛，尤其是面向大西洋海岸的沿海地区。其浆果在传统医学中已被使用了几个世纪。最近的研究表明，不仅浆果，而且叶子也具有相关的抗氧化、抗增殖和抗炎特性，这使得这种植物成为讨论的焦点。我们进行了一项文献系统综述，以总结在其浆果和叶子中鉴定出的酚类化合物和生物活性特性，并寻找该主题的研究空白。检索在三个电子数据库（PubMed、SCOPUS和Web of Science）中使用PRISMA方法进行。纳入标准是浆果、叶子或其提取物的化学成分及其生物活性特性。排除标准是农艺学和考古学研究。关于酚类化合物组成以及浆果和叶子生物活性特性的研究数量仍然有限（11篇文章）。然而，已鉴定出的多种多酚类化合物使得能够推断出它们对抑制核因子-κB转录因子激活、调节炎症介质/酶、诱导细胞凋亡、调节丝裂原活化蛋白激酶、细胞周期停滞以及降低氧化应激的假定作用机制的新见解。这些因素对于其未来作为营养保健品、食品补充剂或药物的用途可能具有重要意义。尽管如此，仍需要更多关于其生物活性的科学证据。
