Ximenes Thalita Vieira Nascimento, Carvalho Raquel, Bonfá Iluska Senna, Santos Vanessa Samúdio, Candeloro Luciane, Alves Flávio Macedo, Silva Denise Brentan, Carollo Carlos Alexandre, Gielow Karine de Cássia Freitas, Silva-Filho Saulo Euclides, Toffoli-Kadri Mônica Cristina
Pharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
Biosciences Institute, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
Pharmaceuticals (Basel). 2022 Oct 13;15(10):1258. doi: 10.3390/ph15101258.
The aim of this study is to evaluate the efficacy of infusion on high-fat diet-induced metabolic disorders in mice and macrophages activation. This study evaluated obesity, insulin resistance, dyslipidemia and hepatic steatosis induced by a high-fat diet in Swiss mice. Cellular parameters in macrophages, such as cell viability (MTT), the production and release of nitric oxide (NO) and hydrogen peroxide (HO), cell spreading, cell adhesion and phagocytosis were determined. Our results showed that treatment with prevented the mentioned conditions, except for the production of hydrogen peroxide. prevented the development of obesity and associated comorbidities, as well as activation of macrophages. In conclusion, is able to prevent obesity and metabolic disorders and macrophages activation, minimizing inflammation and validating the popular use of this plant tea.
本研究的目的是评估[某种物质]输注对高脂饮食诱导的小鼠代谢紊乱及巨噬细胞活化的疗效。本研究评估了高脂饮食在瑞士小鼠中诱导的肥胖、胰岛素抵抗、血脂异常和肝脂肪变性。测定了巨噬细胞中的细胞参数，如细胞活力（MTT）、一氧化氮（NO）和过氧化氢（HO）的产生与释放、细胞铺展、细胞黏附及吞噬作用。我们的结果表明，[某种物质]治疗可预防上述情况，但过氧化氢的产生除外。[某种物质]可预防肥胖及相关合并症的发展以及巨噬细胞的活化。总之，[某种物质]能够预防肥胖和代谢紊乱以及巨噬细胞活化，将炎症降至最低，并证实了这种植物茶的广泛应用。
