Jiang Dengbang, Zou Haoying, Zhang Heng, Zhao Wan, Lan Yaozhong, Yuan Mingwei
National and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, Yunnan Minzu University, Kunming 650500, China.
Polymers (Basel). 2022 Oct 18;14(20):4406. doi: 10.3390/polym14204406.
Poly(L-lactide) (PLLA) and PLLA/poly(trimethylene carbonate) (PTMC) scaffolds characterised by different PLLA:PTMC mass ratios (10:0, 9:1, 8:2, 7:3, 6:4 and 5:5) were prepared via electrospinning. The results showed that increasing the PTMC content in the spinning solution caused the following effects: (1) the diameter of the prepared PLLA/PTMC electrospun fibres gradually increased from 188.12 ± 48.87 nm (10:0) to 584.01 ± 60.68 nm (5:5), (2) electrospun fibres with uniform diameters and no beads could be prepared at the PTMC contents of >30%, (3) the elastic modulus of the fibre initially increased and then decreased, reaching a maximum value of 74.49 ± 8.22 Mpa (5:5) and (4) the elongation at the breaking point of the fibres increased gradually from 24.71% to 344.85%. Compared with the PLLA electrospun fibrous membrane, the prepared PLLA/PTMC electrospun fibrous membrane exhibited considerably improved mechanical properties while maintaining good histocompatibility.
通过静电纺丝制备了具有不同聚乳酸（PLLA）与聚三亚甲基碳酸酯（PTMC）质量比（10:0、9:1、8:2、7:3、6:4和5:5）的聚（L-丙交酯）（PLLA）和PLLA/聚三亚甲基碳酸酯（PTMC）支架。结果表明，纺丝溶液中PTMC含量的增加产生了以下影响：（1）制备的PLLA/PTMC静电纺丝纤维的直径从188.12±48.87 nm（10:0）逐渐增加到584.01±60.68 nm（5:5）；（2）当PTMC含量>30%时，可以制备出直径均匀且无珠粒的静电纺丝纤维；（3）纤维的弹性模量先增加后降低，在质量比为5:5时达到最大值74.49±8.22 Mpa；（4）纤维的断裂伸长率从24.71%逐渐增加到344.85%。与PLLA静电纺丝纤维膜相比，制备的PLLA/PTMC静电纺丝纤维膜在保持良好组织相容性的同时，机械性能有了显著提高。
