用于药物输送应用的聚合物纳米纤维的静电纺丝。
Electrospinning of polymeric nanofibers for drug delivery applications.
机构信息
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; The University of Chinese Academy of Sciences, Beijing 100049, PR China.
出版信息
J Control Release. 2014 Jul 10;185:12-21. doi: 10.1016/j.jconrel.2014.04.018. Epub 2014 Apr 22.
Electrospinning has been recognized as a simple and versatile method for fabrication of polymer nanofibers. Various polymers that include synthetic, natural, and hybrid materials have been successfully electrospun into ultrafine fibers. The inherently high surface to volume ratio of electrospun fibers can enhance cell attachment, drug loading, and mass transfer properties. Drugs ranging from antibiotics and anticancer agents to proteins, DNA, RNA, living cells, and various growth factors have been incorporated into electrospun fibers. This article presents an overview of electrospinning techniques and their application in drug delivery.
静电纺丝已被公认为是制备聚合物纳米纤维的一种简单且通用的方法。各种聚合物，包括合成、天然和混合材料，已成功地被静电纺成超细纤维。静电纺纤维固有的高表面积与体积比可以增强细胞附着、药物负载和传质性能。各种药物，包括抗生素和抗癌药物、蛋白质、DNA、RNA、活细胞和各种生长因子，已被掺入静电纺纤维中。本文介绍了静电纺丝技术及其在药物传递中的应用。
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