Luo G X, Deng J
State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing Key Laboratory for Disease Proteomics, Chongqing 400038, China.
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022 Oct 20;38(10):899-904. doi: 10.3760/cma.j.cn501225-20220720-00299.
Local oxidative stress and inflammatory response are the essential procedures in wound repair, which determine the progress, prognosis, and quality of wound repair. Reactive oxygen species is one of the important indexes reflecting oxidative stress and inflammatory response of body, which is considered as a promising target to be regulated in wound inflammation. Recently, with the rapid development of nanomedicine, our research group and other research groups have successfully developed various diagnosis and treatment reagents for reactive oxygen species through interdisciplinary integration, to monitor and regulate reactive oxygen species in wounds in real time, and to finally achieve the goal of improving the speed and quality of wound repair, thus providing a new strategy and direction for the diagnosis and treatment of local inflammatory response in wounds. This article summarizes reactive oxygen species as the regulatory target of local inflammatory response in wounds, monitoring and precise regulation of reactive oxygen species.
局部氧化应激和炎症反应是伤口修复的关键过程，它们决定了伤口修复的进程、预后和质量。活性氧是反映机体氧化应激和炎症反应的重要指标之一，被认为是伤口炎症中一个有前景的可调控靶点。近年来，随着纳米医学的快速发展，我们研究团队和其他研究团队通过多学科交叉融合，成功开发了多种针对活性氧的诊断和治疗试剂，以实时监测和调控伤口中的活性氧，最终实现提高伤口修复速度和质量的目标，从而为伤口局部炎症反应的诊断和治疗提供了新的策略和方向。本文综述了将活性氧作为伤口局部炎症反应的调控靶点、活性氧的监测及精准调控。
