Ning Meng, Wen Shizhe, Zhou Peiling, Zhang Changzheng
School of Music, Huainan Normal University, Huainan, China.
School of Educational Sciences, Lingnan Normal University, Zhanjiang, China.
Front Psychol. 2022 Oct 10;13:1014202. doi: 10.3389/fpsyg.2022.1014202. eCollection 2022.
Post-traumatic stress disorder (PTSD) is a debilitating sequela of extraordinary traumatic sufferings that threaten personal health and dramatically attenuate the patient's quality of life. Accumulating lines of evidence suggest that functional disorders in the ventral tegmental area (VTA) dopaminergic system contribute substantially to PTSD symptomatology. Notably, music therapy has been shown to greatly ameliorate PTSD symptoms. In this literature review, we focused on whether music improved PTSD symptoms, based on VTA dopaminergic action, including the effects of music on dopamine (DA)-related gene expression, the promotion of DA release and metabolism, and the activation of VTA functional activities. In addition, the strengths and limitations of the studies concerning the results of music therapy on PTSD are discussed. Collectively, music therapy is an effective approach for PTSD intervention, in which the VTA dopaminergic system may hold an important position.
创伤后应激障碍（PTSD）是由异常创伤性痛苦导致的一种使人衰弱的后遗症，这些创伤性痛苦威胁个人健康并显著降低患者的生活质量。越来越多的证据表明，腹侧被盖区（VTA）多巴胺能系统的功能障碍在很大程度上导致了PTSD的症状表现。值得注意的是，音乐疗法已被证明能极大地改善PTSD症状。在这篇文献综述中，我们基于VTA多巴胺能作用，聚焦于音乐是否能改善PTSD症状，包括音乐对多巴胺（DA）相关基因表达的影响、DA释放和代谢的促进作用以及VTA功能活动的激活。此外，还讨论了关于音乐疗法对PTSD治疗结果研究的优势和局限性。总体而言，音乐疗法是一种有效的PTSD干预方法，其中VTA多巴胺能系统可能占据重要地位。
