亚秒级三维 15 氮磁共振成像通过基于仲氢的极化增强实现。
Subsecond Three-Dimensional Nitrogen-15 Magnetic Resonance Imaging Facilitated by Parahydrogen-Based Hyperpolarization.
机构信息
International Tomography Center, SB RAS, 3A Institutskaya Street, Novosibirsk630090, Russia.
Novosibirsk State University, 2 Pirogova Street, Novosibirsk630090, Russia.
出版信息
J Phys Chem Lett. 2022 Nov 10;13(44):10253-10260. doi: 10.1021/acs.jpclett.2c02705. Epub 2022 Oct 27.
Magnetic resonance imaging (MRI) provides unique information about the internal structure and function of living organisms in a non-invasive way. The use of conventional proton MRI for the observation of real-time metabolism is hampered by the dominant signals of water and fat, which are abundant in living organisms. Heteronuclear MRI in conjunction with the hyperpolarization methods does not encounter this issue. In this work, we polarized N nuclei of [N]fampridine (a drug used for the treatment of multiple sclerosis) to the level of 4% in nuclear magnetic resonance (NMR) experiments and 0.7% in MRI studies using spin-lock-induced crossing combined with signal amplification by reversible exchange. Consequently, three-dimensional N MRI of the hyperpolarized N-labeled drug was acquired in 0.1 s with a signal-to-noise ratio of 70. In addition, the NMR signal enhancements for N-enriched fampridine and fampridine with a natural abundance of N nuclei were compared and an explanation for their difference was proposed.
磁共振成像（MRI）以非侵入的方式提供关于活体内部结构和功能的独特信息。由于水和脂肪信号在活体中非常丰富，常规质子 MRI 用于实时观察代谢受到限制。异核 MRI 与极化方法相结合则不会遇到这个问题。在这项工作中，我们将[N]fampridine（一种用于治疗多发性硬化症的药物）的 N 核极化到核磁共振（NMR）实验中的 4%和 MRI 研究中的 0.7%，使用自旋锁定诱导交叉结合可交换信号放大的方法。结果，在 0.1 秒内获得了三维极化 N 标记药物的 N MRI，信噪比为 70。此外，还比较了富 N 的 fampridine 和天然丰度 N 核的 fampridine 的 NMR 信号增强，并对其差异提出了解释。
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