Ayad Bashir, Omolaoye Temidayo S, Louw Nicola, Ramsunder Yashthi, Skosana Bongekile T, Oyeipo Peter I, Du Plessis Stefan S
Department of Physiology, Faculty of Medicine, Misurata University, Misrata, Libya.
Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
Front Reprod Health. 2022 Feb 22;4:822257. doi: 10.3389/frph.2022.822257. eCollection 2022.
Male fertility potential can be influenced by a variety of conditions that frequently coincide. Spermatozoa are particularly susceptible to oxidative damage due to their limited antioxidant capacity and cell membrane rich in polyunsaturated fatty acids (PUFAs). The role of oxidative stress (OS) in the etiology of male infertility has been the primary focus of our Stellenbosch University Reproductive Research Group (SURRG) over the last 10 years. This review aims to provide a novel insight into the impact of OS on spermatozoa and male reproductive function by reviewing the OS-related findings from a wide variety of studies conducted in our laboratory, along with those emerging from other investigators. We will provide a concise overview of the production of reactive oxygen species (ROS) and the development of OS in the male reproductive tract along with the physiological and pathological effects thereof on male reproductive functions. Recent advances in methods and techniques used for the assessment of OS will also be highlighted. We will furthermore consider the current evidence regarding the association between OS and ejaculatory abstinence period, as well as the potential mechanisms involved in the pathophysiology of various systemic diseases such as obesity, insulin resistance, hypertension, and certain mental health disorders which have been shown to cause OS induced male infertility. Finally, special emphasis will be placed on the potential for transferring and incorporating research findings emanating from different experimental studies into clinical practice.
男性生育潜能会受到多种常常同时出现的状况的影响。由于精子的抗氧化能力有限且细胞膜富含多不饱和脂肪酸（PUFA），精子特别容易受到氧化损伤。在过去十年中，氧化应激（OS）在男性不育病因中的作用一直是我们斯泰伦博斯大学生殖研究小组（SURRG）的主要研究重点。本综述旨在通过回顾我们实验室进行的各种研究以及其他研究人员的相关研究结果中与OS相关的发现，对OS对精子和男性生殖功能的影响提供新的见解。我们将简要概述男性生殖道中活性氧（ROS）的产生、OS的发展及其对男性生殖功能的生理和病理影响。还将重点介绍用于评估OS的方法和技术的最新进展。此外，我们将考虑关于OS与射精禁欲期之间关联的现有证据，以及肥胖、胰岛素抵抗、高血压和某些精神健康障碍等各种全身性疾病病理生理学中涉及的潜在机制，这些疾病已被证明会导致OS诱导的男性不育。最后，将特别强调将不同实验研究的研究结果转化并应用于临床实践的潜力。
