Laboratory of Neuropsychopharmacology, College of Fundamental Medicine, Shanghai University of Medicine & Health Science, Shanghai 201318, China.
Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China.
World J Gastroenterol. 2022 Oct 14;28(38):5547-5556. doi: 10.3748/wjg.v28.i38.5547.
The incidence of frailty gradually increases with age. This condition places a heavy burden on modern society, of which the aging population is increasing. Frailty is one of the most complicated clinical syndromes; thus, it is difficult to uncover its underlying mechanisms. Oxidative stress (OS) is involved in frailty in multiple ways. The association between the gut microbiota (GM) and frailty was recently reported. Herein, we propose that OS is involved in the association between the GM and the occurrence of frailty syndrome. An imbalance between oxidation and antioxidants can eventually lead to frailty, and the GM probably participates in this process through the production of reactive oxygen species. On the other hand, OS can disturb the GM. Such dysbiosis consequently induces or exacerbates tissue damage, leading to the occurrence of frailty syndrome. Finally, we discuss the possibility of improving frailty by intervening in the vicious cycle between the imbalance of OS and dysbiosis.
虚弱的发病率随着年龄的增长逐渐增加。这种情况给现代社会带来了沉重的负担，而现代社会的人口老龄化正在加剧。虚弱是最复杂的临床综合征之一，因此很难揭示其潜在的机制。氧化应激（OS）以多种方式参与虚弱。最近有报道称肠道微生物群（GM）与虚弱之间存在关联。在这里，我们提出 OS 参与了 GM 与虚弱综合征发生之间的关联。氧化和抗氧化剂之间的失衡最终可能导致虚弱，而 GM 可能通过产生活性氧来参与这一过程。另一方面，OS 可以扰乱 GM。这种菌群失调继而诱导或加剧组织损伤，导致虚弱综合征的发生。最后，我们讨论了通过干预 OS 失衡和菌群失调之间的恶性循环来改善虚弱的可能性。
