营养、长寿与疾病：从分子机制到干预措施。
Nutrition, longevity and disease: From molecular mechanisms to interventions.
机构信息
Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA; IFOM, FIRC Institute of Molecular Oncology, Via Adamello, 16, 20139 Milano, Italy.
Department of Medicine, SMPH, University of Wisconsin-Madison, Madison, WI, USA; GRECC, William S Middleton Memorial Veterans Hospital, Madison, WI, USA.
出版信息
Cell. 2022 Apr 28;185(9):1455-1470. doi: 10.1016/j.cell.2022.04.002.
Diet as a whole, encompassing food composition, calorie intake, and the length and frequency of fasting periods, affects the time span in which health and functional capacity are maintained. Here, we analyze aging and nutrition studies in simple organisms, rodents, monkeys, and humans to link longevity to conserved growth and metabolic pathways and outline their role in aging and age-related disease. We focus on feasible nutritional strategies shown to delay aging and/or prevent diseases through epidemiological, model organism, clinical, and centenarian studies and underline the need to avoid malnourishment and frailty. These findings are integrated to define a longevity diet based on a multi-pillar approach adjusted for age and health status to optimize lifespan and healthspan in humans.
饮食作为一个整体，包括食物组成、热量摄入以及禁食期的长短和频率，都会影响到维持健康和功能能力的时间跨度。在这里，我们分析了简单生物、啮齿动物、猴子和人类的衰老和营养研究，将长寿与保守的生长和代谢途径联系起来，并概述了它们在衰老和与年龄相关的疾病中的作用。我们关注通过流行病学、模式生物、临床和百岁老人研究表明可行的营养策略，这些策略可以通过延迟衰老和/或预防疾病来发挥作用，并强调需要避免营养不良和虚弱。这些发现被整合在一起，定义了一种基于多支柱方法的长寿饮食，根据年龄和健康状况进行调整，以优化人类的寿命和健康寿命。
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