Schreiber G, Baumann W, Börner A, Lauterbach H, Reiber V, Thiel W
Z Urol Nephrol. 1987 Jun;80(6):329-35.
The normal histological findings of the testicles with simultaneous azoospermia according to the former opinion renders greatly probable an obstruction of the seminal ducts. The reversed case of an ascertained obstruction, however, must not necessarily contain also normal histological structures or normal hormone tests. In the obstruction syndrome in 6 out of 23 cases we find changes in the diameter of the tubule, reductions of the spermatogenesis and changes at the interstice. Imprint-cytologically an increase of pathological spermatides at the cost of normal cell developments is shown. According to this the FSH-values are slightly but statistically significantly increased. LH, PRL and testosterone are found within the normal. For the diagnostic delimitation of the obstruction syndrome from a production azoospermia according to these findings the performance of a biopsy of the testicles with histological evaluation and the determination of the FSH-value. The relatively discrete tubular changes alone cannot be used for the explanation of the discrepancy between anatomical and functional results of the operative reconstruction of the seminal ducts.
根据以往观点，睾丸组织学检查结果正常但同时存在无精子症，极有可能是输精管阻塞。然而，已确诊阻塞的相反情况并不一定也具有正常的组织结构或正常的激素检测结果。在23例阻塞综合征病例中，有6例出现了曲细精管直径改变、生精功能减退以及间质变化。印片细胞学检查显示，病理性精子细胞增多，正常细胞发育减少。据此，卵泡刺激素（FSH）值略有升高，但具有统计学意义。促黄体生成素（LH）、催乳素（PRL）和睾酮水平正常。根据这些结果，为了将阻塞综合征与生精障碍性无精子症进行诊断区分，需要进行睾丸活检并进行组织学评估以及测定FSH值。仅相对轻微的曲细精管变化无法解释输精管手术重建在解剖学和功能结果上的差异。
