用于研究乙型肝炎病毒病理生物学和免疫的动物模型：过去、现在与未来
Animal Models for the Study of Hepatitis B Virus Pathobiology and Immunity: Past, Present, and Future.
作者信息
Zhang Xiaonan, Wang Xiaomeng, Wu Min, Ghildyal Reena, Yuan Zhenghong
机构信息
Centre for Research in Therapeutic Solutions, Faculty of Science and Technology, University of Canberra, Canberra, ACT, Australia.
Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
出版信息
Front Microbiol. 2021 Jul 16;12:715450. doi: 10.3389/fmicb.2021.715450. eCollection 2021.
Abstract
Hepatitis B virus (HBV) infection is a global public health problem that plagues approximately 240 million people. Chronic hepatitis B (CHB) often leads to liver inflammation and aberrant repair which results in diseases ranging from liver fibrosis, cirrhosis, to hepatocellular carcinoma. Despite its narrow species tropism, researchers have established various models for HBV or its related viruses which have provided a wealth of knowledge on viral lifecycle, pathogenesis, and immunity. Here we briefly revisit over five decades of endeavor in animal model development for HBV and summarize their advantages and limitations. We also suggest directions for further improvements that are crucial for elucidation of the viral immune-evasion strategies and for development of novel therapeutics for a functional cure.
摘要
乙型肝炎病毒（HBV）感染是一个全球性的公共卫生问题，困扰着约2.4亿人。慢性乙型肝炎（CHB）常导致肝脏炎症和异常修复，进而引发从肝纤维化、肝硬化到肝细胞癌等一系列疾病。尽管其宿主范围狭窄，但研究人员已建立了多种HBV或其相关病毒的模型，这些模型为病毒生命周期、发病机制和免疫提供了丰富的知识。在此，我们简要回顾五十多年来在HBV动物模型开发方面的努力，并总结其优缺点。我们还提出了进一步改进的方向，这对于阐明病毒免疫逃逸策略和开发功能性治愈的新疗法至关重要。
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