Dehesa Luis, Abuchar Adriana, Nuno-Gonzalez Almudena, Vitiello Magalys, Kerdel Francisco A
Florida Academic Dermatology Center, University of Miami Hospital, Miami, FL 33136, USA.
J Drugs Dermatol. 2012 Aug;11(8):979-87.
Cyclosporine is an immunosuppressive drug that acts selectively on T-cells by inhibiting calcineurin phosphorylase. It has been used in dermatology since its approval for US Food and Drug Administration in 1997 for the use in psoriasis. While indicated only for the treatment of moderate to severe psoriasis, cyclosporine has also been used as an off-label drug for the treatment of various inflammatory skin conditions, including atopic dermatitis, blistering disorders, and connective tissue diseases. In this article, we review the use of cyclosporine in dermatology.
环孢素是一种免疫抑制药物，通过抑制钙调神经磷酸酶磷酸化酶选择性作用于T细胞。自1997年被美国食品药品监督管理局批准用于治疗银屑病以来，它一直在皮肤科领域使用。虽然环孢素仅被批准用于治疗中度至重度银屑病，但它也被用作治疗各种炎症性皮肤病的非适应证用药，包括特应性皮炎、水疱性疾病和结缔组织病。在本文中，我们综述环孢素在皮肤科的应用。
