Department of Dermatology at the University of Texas, Houston, Texas, USA.
J Am Acad Dermatol. 2010 Dec;63(6):925-46; quiz 947-8. doi: 10.1016/j.jaad.2010.02.063.
Cyclosporine is a calcineurin inhibitor that acts selectively on T cells. It has been used in dermatology since 1997 for its US Food and Drug Administration indication of psoriasis and off-label for various other inflammatory skin conditions, including atopic dermatitis, blistering disorders, and connective tissue diseases. In the last decade, many dermatologists have hesitated to use this important drug in their clinical practices because of its toxicity profile. The purpose of this article is to review the mechanism of action of cyclosporine and its current uses and dosing schedules. It is our goal to create a framework in which dermatologists feel comfortable and safe incorporating cyclosporine into their prescribing regimens.
After completing this learning activity, participants should be able to describe the mechanism of action of cyclosporine, recognize the potential role of cyclosporine in dermatology and the evidence to support this role, and incorporate cyclosporine into his or her prescribing regimens.
本综述旨在回顾环孢素的作用机制及其目前的用途和剂量方案。我们的目标是构建一个框架，使皮肤科医生在制定处方方案时感到舒适和安全。
完成本项学习活动后，参与者应能够描述环孢素的作用机制，认识到环孢素在皮肤科中的潜在作用及其支持这一作用的证据，并将环孢素纳入其处方方案中。
