Kutlubay Zekayi, Erdogan Bigen Çakıl, Engin Burhan, Serdaroglu Server
Department of Dermatology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey;
Department of Dermatology, Sadi Konuk Research and Training Hospital, Istanbul, Turkey.
Skinmed. 2016 Apr 1;14(2):105-9. eCollection 2016.
Cyclosporine, a member of the calcineurin inhibitor family, has immunomodulatory effects on T cells. It blocks the earliest stages of the immune response by binding to cyclophilin, thus inhibiting calcineurin. It was initially used for transplant patients to prevent transplant rejections. The main indication for cyclosporine in dermatology is severe psoriasis. Other dermatologic indications for the use of cyclosporine include atopic dermatitis, chronic idiopathic urticaria, pyoderma gangrenosum, and Behçet's disease.
环孢素是钙调神经磷酸酶抑制剂家族的一员，对T细胞具有免疫调节作用。它通过与亲环蛋白结合来阻断免疫反应的最早阶段，从而抑制钙调神经磷酸酶。它最初用于移植患者以预防移植排斥反应。环孢素在皮肤科的主要适应证是重度银屑病。环孢素使用的其他皮肤科适应证包括特应性皮炎、慢性特发性荨麻疹、坏疽性脓皮病和白塞病。
