Zhou Zuoqin, Wang Caiyun, Bai Jingqi, Zeng Zihan, Yang Xiaoyu, Wei Bing, Yang Zheng
Research Center of Anti-aging Chinese Herbal Medicine of Anhui Province, School of Biology and Food Engineering, Fuyang Normal University, Fuyang, China.
Anhui Ecological Fermentation Engineering Research Center for Functional Fruit Beverage, School of Biology and Food Engineering, Fuyang Normal University, Fuyang, China.
Front Bioeng Biotechnol. 2022 Oct 11;10:968065. doi: 10.3389/fbioe.2022.968065. eCollection 2022.
Cancer cells are under oxidative stress associated with the increased generation of reactive oxygen species (ROS). Therefore, increasing the oxidative stress of tumor cells by delivering ROS generators is an effective strategy to induce apoptosis of cancer cells. Herein, we reported a hybrid nanoparticle based on lactobionic acid (LA) modified chitosan and cinnamaldehyde (CA) modified chitosan, which possesses both active tumor-targeting ability and ROS regulation ability, in order to have a synergistic effect with the anti-tumor drug doxorubicin (DOX). LA can improve the tumor-targeting ability and cellular accumulation of these nanoparticles, and CA can induce apoptotic cell death through ROS generation, mitochondrial permeability transition and caspase activation. The particle size and distribution as well as drug release profiles of these nanoparticles were observed. and antitumor studies demonstrated that the hybrid nanoparticles show a significant synergistic antitumor effect. Thus, we anticipate that the hybrid nanoparticles have promising potential as an anticancer drug carrier.
癌细胞处于与活性氧（ROS）生成增加相关的氧化应激状态。因此，通过递送ROS生成剂来增加肿瘤细胞的氧化应激是诱导癌细胞凋亡的有效策略。在此，我们报道了一种基于乳糖酸（LA）修饰的壳聚糖和肉桂醛（CA）修饰的壳聚糖的杂化纳米颗粒，其兼具主动肿瘤靶向能力和ROS调节能力，以便与抗肿瘤药物阿霉素（DOX）产生协同作用。LA可提高这些纳米颗粒的肿瘤靶向能力和细胞摄取，而CA可通过ROS生成、线粒体通透性转换和半胱天冬酶激活诱导细胞凋亡。观察了这些纳米颗粒的粒径和分布以及药物释放曲线。抗肿瘤研究表明，杂化纳米颗粒显示出显著的协同抗肿瘤作用。因此，我们预期杂化纳米颗粒作为抗癌药物载体具有广阔的应用前景。
