Department of General Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo University, Ningbo 315040, China.
Department of Clinical Laboratory, Ningbo Medical Center Lihuili Hospital, Ningbo University, Ningbo 315040, China.
Oxid Med Cell Longev. 2022 Oct 17;2022:2663748. doi: 10.1155/2022/2663748. eCollection 2022.
The elucidation of the action site, mechanism of Leucine-Zipper-like Transcription Regulator-1 (LZTR1) and its relationship with RAS-MAPK signaling pathway attracts more and more scholars to focus on the researches of LZTR1 and its role in tumorigenesis. However, there was no pan-cancer analysis between LZTR1 and human tumors reported before. Therefore, we are the first to investigate the potential oncogenic roles of LZTR1 across all tumor types based on the datasets of TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus). LZTR1 plays a double-edged role in tumor development and prognosis. We found that the high expression of LZTR1 brings better outcomes in esophageal carcinoma (ESCA) and head and neck squamous cell carcinoma (HNSC) but brings worth outcomes in uveal melanoma (UVM), adrenocortical carcinoma (ACC), liver hepatocellular carcinoma (LIHC), and prostate adenocarcinoma (PRAD). Moreover, the expression of LZTR1 also strongly associated with pathological in ACC and bladder urothelial carcinoma (BLCA). We also found that the LZTR1 expression was associated with some immune cell infiltration including endothelial cells, regulatory T cells (Tregs), T cell CD8+, natural killer cells (NK cell), macrophages, neutrophil granulocyte, and cancer-associated fibroblasts in different cancers. Missense mutation in LZTR1 was detected in most cancers from TCGA datasets. Finally, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene Body (GO) method was used to explain the pathogenesis of LZTR1. Our pan-cancer study provides a relatively comprehensive understanding of the carcinogenic role of LZTR1 in human tumors.
LZTR1 的作用位点阐明、机制及其与 RAS-MAPK 信号通路的关系，引起了越来越多的学者关注 LZTR1 及其在肿瘤发生中的作用。然而，此前尚未有关于 LZTR1 与人类肿瘤的泛癌症分析。因此，我们首次基于 TCGA（癌症基因组图谱）和 GEO（基因表达综合数据库）数据集，研究 LZTR1 在所有肿瘤类型中的潜在致癌作用。LZTR1 在肿瘤发生和预后中扮演着双刃剑的角色。我们发现，LZTR1 的高表达在食管癌（ESCA）和头颈部鳞状细胞癌（HNSC）中带来更好的结果，但在葡萄膜黑色素瘤（UVM）、肾上腺皮质癌（ACC）、肝肝细胞癌（LIHC）和前列腺腺癌（PRAD）中带来较差的结果。此外，LZTR1 的表达也与 ACC 和膀胱尿路上皮癌（BLCA）的病理密切相关。我们还发现，LZTR1 的表达与内皮细胞、调节性 T 细胞（Tregs）、T 细胞 CD8+、自然杀伤细胞（NK 细胞）、巨噬细胞、中性粒细胞和癌症相关成纤维细胞等多种免疫细胞浸润有关，在不同的癌症中。TCGA 数据集中的大多数癌症都检测到 LZTR1 的错义突变。最后，京都基因与基因组百科全书（KEGG）通路和基因体（GO）方法被用来解释 LZTR1 的发病机制。我们的泛癌症研究为 LZTR1 在人类肿瘤中的致癌作用提供了较为全面的认识。
