行为变异型额颞叶痴呆的功能连接。
Functional connectivity in behavioral variant frontotemporal dementia.
机构信息
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm, Sweden.
出版信息
Brain Behav. 2022 Dec;12(12):e2790. doi: 10.1002/brb3.2790. Epub 2022 Oct 28.
INTRODUCTION
Functional connectivity (FC)-which reflects relationships between neural activity in different brain regions-has been used to explore the functional architecture of the brain in neurodegenerative disorders. Although an increasing number of studies have explored FC changes in behavioral variant frontotemporal dementia (bvFTD), there is no focused, in-depth review about FC in bvFTD.
METHODS
Comprehensive literature search and narrative review to summarize the current field of FC in bvFTD.
RESULTS
(1) Decreased FC within the salience network (SN) is the most consistent finding in bvFTD; (2) FC changes extend beyond the SN and affect the interplay between networks; (3) results within the Default Mode Network are mixed; (4) the brain as a network is less interconnected and less efficient in bvFTD; (5) symptoms, functional impairment, and cognition are associated with FC; and (6) the functional architecture resembles patterns of neuropathological spread.
CONCLUSIONS
FC has potential as a biomarker, and future studies are expected to advance the field with multicentric initiatives, longitudinal designs, and methodological advances.
简介
功能连接（FC）反映了不同脑区之间神经活动的关系，已被用于探索神经退行性疾病中大脑的功能结构。尽管越来越多的研究探讨了行为变异额颞叶痴呆（bvFTD）中的 FC 变化，但对于 bvFTD 中的 FC 尚无集中、深入的综述。
方法
全面的文献检索和叙述性综述，以总结 bvFTD 中 FC 的当前领域。
结果
（1）突显网络（SN）内的 FC 降低是 bvFTD 中最一致的发现；（2）FC 变化不仅限于 SN，还影响网络之间的相互作用；（3）默认模式网络内的结果不一致；（4）bvFTD 中的大脑作为网络的连接性降低，效率降低；（5）症状、功能障碍和认知与 FC 相关；（6）功能结构类似于神经病理学传播的模式。
结论
FC 具有作为生物标志物的潜力，预计未来的研究将通过多中心倡议、纵向设计和方法学进展来推动该领域的发展。
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