Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China.
Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China.
Food Chem. 2023 Mar 15;404(Pt B):134605. doi: 10.1016/j.foodchem.2022.134605. Epub 2022 Oct 14.
Astaxanthin, a xanthophyll carotenoid, has attracted considerable attention owing to its unique molecular structure and excellent antioxidant properties. Due to its structural particularity, it has many geometrical and optical isomers in the diet; Interestingly, the human body has considerable quantity of Z- and optical isomers despite the intake of E- and (3S,3'S) isomers. However, there remains no systematic analysis and summary of astaxanthin and its isomers regarding health benefits and bioavailability. To address this need, this review details the latest research progress of biological activities related to oxidative damage, and these effects are more obvious in Z- and (3S,3'S)-isomers from the existing research. In addition, we outline a comprehensive analysis of the bioavailability of dietary astaxanthin and its isomers from the perspective of transporter-mediated process (e.g. SR-BI, CD36). Further nvestigation of astaxanthin and its isomers is expected to improve human health and promote their applications in future healthcare-related products.
虾青素是一种叶黄素类胡萝卜素，由于其独特的分子结构和优异的抗氧化性能而备受关注。由于其结构的特殊性，它在饮食中有许多几何和光学异构体;有趣的是，尽管摄入了 E-和(3S,3'S)异构体，人体仍有相当数量的 Z-和光学异构体。然而，关于虾青素及其异构体对健康的益处和生物利用度，仍没有系统的分析和总结。为了解决这一需求，本综述详细介绍了与氧化损伤相关的生物活性的最新研究进展，并且这些影响在现有的研究中在 Z-和(3S,3'S)-异构体中更为明显。此外，我们从转运体介导的过程(如 SR-BI、CD36)的角度概述了饮食中虾青素及其异构体生物利用度的综合分析。进一步研究虾青素及其异构体有望改善人类健康，并促进其在未来与医疗保健相关的产品中的应用。
