Department of Chemistry, Faculty of Science & Technology, Meijo University, Shiogamaguchi, Tempaku-ku, Nagoya 468-8502, Japan.
Department of Materials Process Engineering, Nagoya University, Nagoya, Aichi 464-8603, Japan.
J Agric Food Chem. 2021 Mar 24;69(11):3489-3495. doi: 10.1021/acs.jafc.1c00087. Epub 2021 Mar 9.
The purpose of the present study was to clarify the differences in the bioavailability and tissue accumulation efficiency between (all-)- and ()-astaxanthin. Astaxanthin with a high proportion of the -isomer (especially rich in the 9- and 13-isomers) was prepared from (all-)-astaxanthin by thermal treatment and solid-liquid separation. The all--isomer- or -isomer-rich diet was fed to male rats for 2 weeks. After the feeding period, blood and tissue samples were collected, and their astaxanthin levels were evaluated. The -isomer-rich astaxanthin diet resulted in higher levels of astaxanthin in blood and many tissues (in particular, skin, lung, prostate, and eye) compared to the all--isomer-rich diet. Moreover, the -isomer-rich diet enhanced the level of the 13-isomer in blood and tissues rather than that of the 9-isomer. These results strongly supported that astaxanthin -isomers have greater bioavailability and tissue accumulation efficiency than the all--isomer. Moreover, (13)-astaxanthin would have higher bioavailability and tissue accumulation than the other isomers.
本研究旨在阐明全-和（）-虾青素在生物利用度和组织积累效率方面的差异。通过热处理和固液分离，从全-虾青素中制备出高比例（特别是富含 9-和 13-异构体）的虾青素。将富含全--异构体或 -异构体的饮食喂养给雄性大鼠 2 周。喂养期结束后，采集血液和组织样本，并评估其虾青素水平。与富含全--异构体的饮食相比，富含 -异构体的虾青素饮食可使血液和许多组织（特别是皮肤、肺、前列腺和眼睛）中的虾青素水平更高。此外，富含 -异构体的饮食可提高血液和组织中 13-异构体的水平，而不是 9-异构体的水平。这些结果强烈支持虾青素 -异构体比全--异构体具有更高的生物利用度和组织积累效率。此外，（13）-虾青素的生物利用度和组织积累可能高于其他异构体。
