Guo Ling-Chuan, Lv Zhanlu, Zhu Tingting, He Guanhao, Hu Jianxiong, Xiao Jianpeng, Liu Tao, Yu Shengbing, Zhang Jinliang, Zhang Han, Ma Wenjun
State Key Laboratory of Environmental Criteria and Risk Assessment, State Environmental Protection Key Laboratory of Ecological Effect and Risk Assessment of Chemicals, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
State Environmental Protection Key Laboratory of Drinking Water Source Management and Technology, Shenzhen Key Laboratory of Emerging Contaminants Detection and Control in Water Environment, Guangdong Engineering Research Center of Low Energy Sewage Treatment, Shenzhen Academy of Environmental Sciences, Shenzhen 518001, China.
Sci Total Environ. 2023 Feb 1;858(Pt 1):159746. doi: 10.1016/j.scitotenv.2022.159746. Epub 2022 Oct 25.
E-waste handling activities release large quantities of polychlorinated biphenyls (PCBs) and halogen flame retardants (HFRs) into the surrounding area, creating a high exposure risk for local residents. However, the possibility of PCBs and HFRs exposure contributing to renal injury has not been extensively studied. To fill this knowledge gap, we conducted an epidemiological analysis of adolescents and adults recruited from an e-waste recycling area and a control area. Some PCBs and HFRs compounds were statistically significantly associated with the levels of β-microglobulin (β-MG), blood urea nitrogen (BUN), serum creatinine (SCr), and uric acid, with thyroid hormone-related genes found to partly mediate these associations. The interactions of PCBs and HFRs with metals also influenced renal function indexes. Exposure to high concentrations of PCBs and HFRs resulted in higher levels of β-MG and lower levels of BUN and SCr in the exposed group. As indicated by the elevated β-MG levels, high exposure to PCBs and HFRs may increase the risk of early renal injury for adolescents. These findings help to clarify the impacts of PCBs and HFRs on renal function and highlight the need to protect the health of residents in regions impacted by e-waste handling activities.
电子垃圾处理活动会向周边地区释放大量多氯联苯（PCBs）和卤代阻燃剂（HFRs），给当地居民带来高暴露风险。然而，多氯联苯和卤代阻燃剂暴露导致肾损伤的可能性尚未得到广泛研究。为填补这一知识空白，我们对从电子垃圾回收区和对照区招募的青少年和成年人进行了一项流行病学分析。一些多氯联苯和卤代阻燃剂化合物与β-微球蛋白（β-MG）、血尿素氮（BUN）、血清肌酐（SCr）和尿酸水平在统计学上有显著关联，发现甲状腺激素相关基因部分介导了这些关联。多氯联苯和卤代阻燃剂与金属的相互作用也影响肾功能指标。暴露于高浓度的多氯联苯和卤代阻燃剂导致暴露组β-MG水平升高，BUN和SCr水平降低。正如β-MG水平升高所示，高暴露于多氯联苯和卤代阻燃剂可能会增加青少年早期肾损伤的风险。这些发现有助于阐明多氯联苯和卤代阻燃剂对肾功能的影响，并突出了保护受电子垃圾处理活动影响地区居民健康的必要性。
