State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Chin J Nat Med. 2022 Oct;20(10):773-794. doi: 10.1016/S1875-5364(22)60224-3.
Tetracycline (TC) natural products possess a variety of remarkable bioactivities and diverse structures. They are an important and fertile source for developing novel drugs. As one of the most successful drug families, TC antibiotics have been in clinical use for over seven decades, and continue to make an important contribution to human health nowadays. To date, studies on TC natural products and their biosynthesis have revealed numerous novel biochemical mechanisms and regulatory elements, which facilitates the rational metabolic engineering studies for generating novel bioactive TC analogs and inspires the development of new synthetic biology tools. In this review, we provide a comprehensive overview on the discovery, biosynthesis, and engineering of the existing TC natural products. These analyses will be of great value for the discovery, design and development of novel TC drugs in the future.
四环类天然产物具有多种显著的生物活性和多样的结构。它们是开发新型药物的重要而丰富的来源。作为最成功的药物家族之一，四环类抗生素已经在临床使用了七十多年，并且如今仍在为人类健康做出重要贡献。迄今为止，四环类天然产物及其生物合成的研究揭示了许多新的生化机制和调控元件，这有助于对产生新型生物活性四环类类似物进行合理的代谢工程研究，并启发了新的合成生物学工具的开发。在这篇综述中，我们全面概述了现有四环类天然产物的发现、生物合成和工程改造。这些分析对于未来四环类药物的发现、设计和开发将具有重要价值。
