高龄父亲：对精子参数、辅助生殖结局和后代健康的影响。
Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health.
机构信息
Department of Anatomical Sciences, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Department of Pediatrics, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.
出版信息
Reprod Biol Endocrinol. 2020 Nov 13;18(1):110. doi: 10.1186/s12958-020-00668-y.
Abstract
Many factors, including postponement of marriage, increased life expectancy, and improved success with assisted reproductive technologies have been contributing to increased paternal age in developed nations. This increased average paternal age has led to concerns about adverse effects of advanced paternal age on sperm quality, assisted reproductive outcomes, and the health of the offspring conceived by older fathers. This review discusses the association between advanced paternal age and sperm parameters, assisted reproduction success rates, and offspring health.
摘要
许多因素，包括推迟婚姻、预期寿命的延长和辅助生殖技术成功率的提高，都导致了发达国家父亲年龄的增长。这种平均父亲年龄的增长引起了人们对高龄父亲的精子质量、辅助生殖结果和由年龄较大的父亲所生育后代的健康产生不利影响的担忧。本文讨论了高龄父亲与精子参数、辅助生殖成功率和后代健康之间的关系。
相似文献
1
Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health.高龄父亲：对精子参数、辅助生殖结局和后代健康的影响。
Reprod Biol Endocrinol. 2020 Nov 13;18(1):110. doi: 10.1186/s12958-020-00668-y.
2
Higher incidence of embryonic defects in mouse offspring conceived with assisted reproduction from fathers with sperm epimutations.辅助生殖技术获得的胚胎，其父亲精子发生表观遗传突变，胚胎缺陷发生率更高。
Hum Mol Genet. 2023 Dec 12;33(1):48-63. doi: 10.1093/hmg/ddad160.
3
Can a father be too old?父亲的年龄会太大吗？
Fertil Steril. 2022 Dec;118(6):999-1000. doi: 10.1016/j.fertnstert.2022.09.021. Epub 2022 Oct 26.
4
Management and counseling of the male with advanced paternal age.高龄男性的管理与咨询
Fertil Steril. 2017 Feb;107(2):324-328. doi: 10.1016/j.fertnstert.2016.11.018. Epub 2017 Jan 6.
5
Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring.父亲年龄增加对精子质量、生殖结局及子代相关表观遗传风险的影响。
Reprod Biol Endocrinol. 2015 Apr 19;13:35. doi: 10.1186/s12958-015-0028-x.
6
Impact of Advanced Paternal Age on Fertility and Risks of Genetic Disorders in Offspring.高龄父亲对生育能力和后代遗传疾病风险的影响。
Genes (Basel). 2023 Feb 14;14(2):486. doi: 10.3390/genes14020486.
7
Infertility in the Aging Male.老年男性不育症
Curr Urol Rep. 2018 May 17;19(7):54. doi: 10.1007/s11934-018-0802-3.
8
Advanced Paternal Age Affects Sperm Count and Anogenital Distance in Mouse Offspring.父亲年龄过大影响小鼠后代的精子数量和肛门生殖距离。
Reprod Sci. 2018 Apr;25(4):515-522. doi: 10.1177/1933719118759441.
9
Impact of paternal age on assisted reproductive technology outcomes and offspring health: a systematic review.父亲年龄对辅助生殖技术结局和后代健康的影响：系统评价。
Andrology. 2023 Sep;11(6):973-986. doi: 10.1111/andr.13385. Epub 2023 Jan 22.
10
Paternal age and assisted reproductive technology: problem solver or trouble maker?父龄与辅助生殖技术：解决问题还是制造麻烦？
Panminerva Med. 2019 Jun;61(2):138-151. doi: 10.23736/S0031-0808.18.03512-7. Epub 2018 Jul 18.
引用本文的文献
1
Impact of Chromosomal Structural Rearrangements on IVF Laboratory Outcomes in PGT-SR Cycles: A Propensity Score Matching-Based Study.染色体结构重排对PGT-SR周期体外受精实验室结局的影响：一项基于倾向评分匹配的研究
Life (Basel). 2025 Aug 11;15(8):1266. doi: 10.3390/life15081266.
2
Exploring the characters of sperm lipid peroxidation, enzymatic antioxidant activity, and spermatozoa zona binding capacity with aging in dogs.探索犬类衰老过程中精子脂质过氧化、酶促抗氧化活性及精子与透明带结合能力的特征。
Sci Rep. 2025 Aug 22;15(1):30976. doi: 10.1038/s41598-025-16410-w.
3
Analysis of Factors of Variation in Characteristics of Boar Ejaculates.公猪射精特性变异因素分析
Animals (Basel). 2025 Jul 11;15(14):2043. doi: 10.3390/ani15142043.
4
Medication, age and abstinence days associated with low semen quality: A cross-sectional study in more than 7000 men visiting the centre for reproductive medicine.与精液质量低下相关的药物、年龄和禁欲天数：对7000多名前往生殖医学中心就诊男性的横断面研究
PLoS One. 2025 Jul 18;20(7):e0326795. doi: 10.1371/journal.pone.0326795. eCollection 2025.
5
Paternal and maternal exposures to per- and polyfluoroalkyl substances (PFAS) and birth outcomes: a multi-country cohort study.父母接触全氟和多氟烷基物质（PFAS）与出生结局：一项多国队列研究。
Environ Health. 2025 Jul 12;24(1):48. doi: 10.1186/s12940-025-01199-y.
6
Development of a single-center predictive model for conventional in vitro fertilization outcomes excluding total fertilization failure: implications for protocol selection.建立排除完全受精失败的单中心常规体外受精结局预测模型：对方案选择的意义
J Ovarian Res. 2025 Jul 2;18(1):138. doi: 10.1186/s13048-025-01728-w.
7
Characterization of microRNA and Metabolite Profiles of Seminal Extracellular Vesicles in Boars.公猪精液细胞外囊泡的微小RNA和代谢物谱特征分析
Animals (Basel). 2025 Jun 1;15(11):1631. doi: 10.3390/ani15111631.
8
Advanced Paternal Age and Sperm Proteome Dynamics: A Possible Explanation for Age-Associated Male Fertility Decline.父亲年龄增长与精子蛋白质组动态变化：对与年龄相关的男性生育能力下降的一种可能解释。
Cells. 2025 May 30;14(11):813. doi: 10.3390/cells14110813.
9
Extracellular Vesicles in the Aging Male Reproductive System: Progresses and Perspectives.衰老男性生殖系统中的细胞外囊泡：进展与展望
Adv Exp Med Biol. 2025;1469:375-394. doi: 10.1007/978-3-031-82990-1_16.
10
Male aging in germ cells: What are we inheriting?生殖细胞中的男性衰老：我们遗传了什么？
Genet Mol Biol. 2025 Feb 18;47Suppl 1(Suppl 1):e20240052. doi: 10.1590/1678-4685-GMB-2024-0052. eCollection 2025.
本文引用的文献
1
Female ageing affects the DNA repair capacity of oocytes in IVF using a controlled model of sperm DNA damage in mice.女性衰老会影响 IVF 中卵母细胞的 DNA 修复能力，这是通过在小鼠中控制精子 DNA 损伤模型来实现的。
Hum Reprod. 2020 Mar 27;35(3):529-544. doi: 10.1093/humrep/dez308.
2
Male ageing is negatively associated with the chance of live birth in IVF/ICSI cycles for idiopathic infertility.男性衰老与特发性不孕的 IVF/ICSI 周期中活产机会呈负相关。
Hum Reprod. 2019 Dec 1;34(12):2523-2532. doi: 10.1093/humrep/dez223.
3
Associations of parental age with offspring all-cause and cause-specific adult mortality.父母年龄与子女全因和特定原因成人死亡率的关联。
Sci Rep. 2019 Nov 19;9(1):17097. doi: 10.1038/s41598-019-52853-8.
4
The effects of aging on semen parameters and sperm DNA fragmentation.衰老对精液参数和精子DNA片段化的影响。
JBRA Assist Reprod. 2020 Jan 30;24(1):82-86. doi: 10.5935/1518-0557.20190058.
5
Age-related changes in human sperm DNA integrity.人类精子DNA完整性的年龄相关变化。
Aging (Albany NY). 2019 Aug 13;11(15):5399-5411. doi: 10.18632/aging.102120.
6
Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles.高龄父亲并不会影响卵母捐赠周期中囊胚活检胚胎的非整倍体率。
J Assist Reprod Genet. 2019 Oct;36(10):2039-2045. doi: 10.1007/s10815-019-01549-z. Epub 2019 Aug 5.
7
Impact of advanced paternal age on the intracytoplasmic sperm injection (ICSI) outcomes in donor egg cycles.父亲高龄对供卵周期卵胞浆内单精子注射（ICSI）结局的影响。
Transl Androl Urol. 2019 Mar;8(Suppl 1):S22-S30. doi: 10.21037/tau.2018.12.13.
8
Maternal, infant and childhood risks associated with advanced paternal age: The need for comprehensive counseling for men.与父亲年龄较大相关的母婴儿童风险：男性需要全面的咨询。
Maturitas. 2019 Jul;125:81-84. doi: 10.1016/j.maturitas.2019.03.020. Epub 2019 Mar 28.
9
Male age is associated with sperm DNA/chromatin integrity.男性年龄与精子 DNA/染色质完整性有关。
Aging Male. 2020 Dec;23(5):822-829. doi: 10.1080/13685538.2019.1600496. Epub 2019 Apr 9.
10
Advanced Paternal Age and Early Onset of Schizophrenia in Sporadic Cases: Not Confounded by Parental Polygenic Risk for Schizophrenia.高龄父亲与散发性精神分裂症发病年龄早有关：与精神分裂症的双亲多基因风险无关。
Biol Psychiatry. 2019 Jul 1;86(1):56-64. doi: 10.1016/j.biopsych.2019.01.023. Epub 2019 Feb 7.
Zotero 插件