Galluzzi Lorenzo, Kroemer Guido
Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA.
Centre de Recherche des Cordeliers, Equipe la Bellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France; Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
Trends Immunol. 2022 Dec;43(12):950-952. doi: 10.1016/j.it.2022.10.008. Epub 2022 Oct 25.
Endoplasmic reticulum stress can stimulate calreticulin (CALR) presentation on the cell surface, promoting the phagocytic uptake of stressed cells by myeloid cells. Recent findings from Wattrus et al. demonstrate that zebrafish and mouse embryonic macrophages engulf CALR-exposing nascent hematopoietic stem cells to ensure the selective survival of stem cells apt for adult hematopoiesis.
内质网应激可刺激钙网蛋白（CALR）在细胞表面呈递，促进骨髓细胞对应激细胞的吞噬摄取。Wattrus等人最近的研究结果表明，斑马鱼和小鼠胚胎巨噬细胞会吞噬暴露CALR的新生造血干细胞，以确保适合成年造血的干细胞选择性存活。
