Jensen L S, Juhl C O, Mulvany M J
Acta Physiol Scand. 1987 Aug;130(4):649-56. doi: 10.1111/j.1748-1716.1987.tb08188.x.
The properties of isolated small oesophageal and mesenteric veins were investigated in a rabbit model subjected to a 4-week period of portal vein stenosis. The animals developed oesophageal varices and these together with the small mesenteric veins were mounted on a myograph. Compared with sham-operated controls portal hypertension resulted in an increased normalized inner radius and media thickness of the oesophageal veins resulting in a non-significant increase in the media to lumen ratio, while the inner radius decreased as media thickness increased in mesenteric veins resulting in a significant (P less than 0.01) increase in the media to lumen ratio. When activated, the active wall tension of both the oesophageal and mesenteric veins was increased following portal hypertension, but the active media stress was unchanged. The EC50 for noradrenaline and angiotensin II did not change in portal hypertensive vessels compared with controls and was equal in oesophageal and mesenteric vessels. The ability of isoprenaline and serotonin to relax pre-contracted vessels of both types was reduced by the portal hypertension. The results of these studies suggest that the development of oesophageal varices is not only due to increased portal venous pressure.
在门静脉狭窄4周的兔模型中，研究了分离出的小食管静脉和肠系膜静脉的特性。动物出现了食管静脉曲张，并将这些曲张静脉与小肠系膜静脉一起安装在肌动描记器上。与假手术对照组相比，门静脉高压导致食管静脉的归一化内径和中膜厚度增加，中膜与管腔比值增加但无统计学意义，而肠系膜静脉内径随中膜厚度增加而减小，导致中膜与管腔比值显著增加（P<0.01）。激活后，门静脉高压后门静脉和肠系膜静脉的主动壁张力均增加，但主动中膜应力未改变。与对照组相比，门静脉高压血管中去甲肾上腺素和血管紧张素II的半数有效浓度（EC50）没有变化，且在食管和肠系膜血管中相等。门静脉高压降低了异丙肾上腺素和5-羟色胺使两种类型预收缩血管舒张的能力。这些研究结果表明，食管静脉曲张的发生不仅是由于门静脉压力升高。
