Section of Clinical Psychology, Leiden University, Leiden, The Netherlands.
Section of Clinical Psychology, Faculty of Social and Behavioural Sciences, Institute of Psychology, Leiden University, P.O. Box 9555, 2300 RB, Leiden, The Netherlands.
AIDS Behav. 2023 May;27(5):1694-1702. doi: 10.1007/s10461-022-03901-4. Epub 2022 Oct 28.
The aim of this study was to investigate the long-term effectiveness (3-4 years later) of an online intervention that was previously found to effectively reduce depressive symptoms in people with HIV on the short term. Participants were people with HIV who had participated in the large RCT on the short-term effectiveness of the guided online intervention. The primary outcome measure was depressive symptoms [Patient Health Questionnaire-9 (PHQ-9)] and the secondary outcome measure was anxiety symptoms [Generalized Anxiety Disorder-2 (GAD-2) scale]. Forty-seven participants completed the long-term follow-up. PHQ-9 scores, previously found to have been significantly reduced on the short term, remained low on the long term. GAD-2 scores did not decrease significantly on the short term, however, on the long term, a significant decrease was found. The intervention may not only be effective in lowering depressive symptoms on the short term but also retain the results on the long term.Trial registration International Clinical Trials Registry Platform, NL8448, March 3, 2020.
本研究旨在探究一项在线干预措施的长期效果（3-4 年后），该干预措施此前已被证明在短期内能有效减轻 HIV 感染者的抑郁症状。参与者为曾参加过关于该在线干预短期效果的大型 RCT 的 HIV 感染者。主要结局指标为抑郁症状[患者健康问卷-9（PHQ-9）]，次要结局指标为焦虑症状[广泛性焦虑障碍-2（GAD-2）量表]。47 名参与者完成了长期随访。PHQ-9 评分此前在短期内显著降低，在长期内仍保持较低水平。GAD-2 评分在短期内没有显著下降，但在长期内发现有显著下降。该干预措施不仅可能在短期内有效降低抑郁症状，而且还能长期保持效果。
试验注册 国际临床试验注册平台，NL8448，2020 年 3 月 3 日。
