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EB 病毒编码 microRNA-BART18-3p 通过靶向从头脂肪生成促进结直肠癌进展。

Epstein-Barr Virus-Encoded MicroRNA-BART18-3p Promotes Colorectal Cancer Progression by Targeting De Novo Lipogenesis.

机构信息

Beijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical University, Beijing, 100069, P. R. China.

Department of Oncology, Capital Medical University, Beijing, 100069, P. R. China.

出版信息

Adv Sci (Weinh). 2022 Dec;9(35):e2202116. doi: 10.1002/advs.202202116. Epub 2022 Oct 28.

DOI:10.1002/advs.202202116
PMID:36307872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9762317/
Abstract

The Epstein-Barr virus (EBV) genome encodes a cluster of 22 viral microRNAs, called miR-BamHI-A rightward transcripts (miR-BARTs), which are shown to promote the development of cancer. Here, this study reports that EBV-miR-BART18-3p is highly expressed in colorectal cancer (CRC) and is closely associated with the pathological and advanced clinical stages of CRC. Ectopic expression of EBV-miR-BART18-3p leads to increased migration and invasion capacities of CRC cells in vitro and causes tumor metastasis in vivo. Mechanistically, EBV-miR-BART18-3p activates the hypoxia inducible factor 1 subunit alpha/lactate dehydrogenase A axis by targeting Sirtuin, which promotes lactate accumulation and acetyl-CoA production in CRC cells under hypoxic condition. Increased acetyl-CoA utilization subsequently leads to histone acetylation of fatty acid synthase and fatty acid synthase-dependent fat synthesis, which in turn drives de novo lipogenesis. The oncogenic role of EBV-miR-BART18-3p is confirmed in the patient-derived tumor xenograft mouse model. Altogether, the findings define a novel mechanism of EBV-miR-BART18-3p in CRC development through the lipogenesis pathway and provide a potential clinical intervention target for CRC.

摘要

EB 病毒（EBV）基因组编码了一簇 22 个病毒 microRNAs，称为 miR-BamHI-A 右向转录物（miR-BARTs），这些 microRNAs 被证明可以促进癌症的发展。本研究报告称，EBV-miR-BART18-3p 在结直肠癌（CRC）中高度表达，并且与 CRC 的病理和晚期临床阶段密切相关。EBV-miR-BART18-3p 的异位表达导致 CRC 细胞体外迁移和侵袭能力增加，并导致体内肿瘤转移。在机制上，EBV-miR-BART18-3p 通过靶向沉默调节蛋白（Sirtuin）激活缺氧诱导因子 1 亚基α/乳酸脱氢酶 A 轴，在缺氧条件下促进 CRC 细胞中乳酸的积累和乙酰辅酶 A 的产生。增加的乙酰辅酶 A 利用率随后导致脂肪酸合成酶的组蛋白乙酰化和脂肪酸合成酶依赖性脂肪合成，从而推动从头脂肪生成。EBV-miR-BART18-3p 的致癌作用在患者来源的肿瘤异种移植小鼠模型中得到了证实。总之，这些发现通过脂肪生成途径定义了 EBV-miR-BART18-3p 在 CRC 发展中的新机制，并为 CRC 提供了一个潜在的临床干预靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a87/9762317/de94a9b1314c/ADVS-9-2202116-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a87/9762317/8afa7f8839c7/ADVS-9-2202116-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a87/9762317/eb144b0007b8/ADVS-9-2202116-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a87/9762317/e95ac95546de/ADVS-9-2202116-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a87/9762317/8c0c651936a9/ADVS-9-2202116-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a87/9762317/9e76c9f7ebdc/ADVS-9-2202116-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a87/9762317/de94a9b1314c/ADVS-9-2202116-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a87/9762317/8afa7f8839c7/ADVS-9-2202116-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a87/9762317/eb144b0007b8/ADVS-9-2202116-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a87/9762317/e95ac95546de/ADVS-9-2202116-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a87/9762317/8c0c651936a9/ADVS-9-2202116-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a87/9762317/9e76c9f7ebdc/ADVS-9-2202116-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a87/9762317/de94a9b1314c/ADVS-9-2202116-g004.jpg

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本文引用的文献

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Semin Cancer Biol. 2022 Nov;86(Pt 2):943-954. doi: 10.1016/j.semcancer.2021.10.004. Epub 2021 Oct 14.
2
Pathophysiological mechanisms and clinical evidence of relationship between Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease.非酒精性脂肪性肝病 (NAFLD) 与心血管疾病之间关系的病理生理机制和临床证据。
Rev Cardiovasc Med. 2021 Sep 24;22(3):755-768. doi: 10.31083/j.rcm2203082.
3
Hypoxia-Inducible Exosomes Facilitate Liver-Tropic Premetastatic Niche in Colorectal Cancer.
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Clin Epigenetics. 2025 Feb 22;17(1):34. doi: 10.1186/s13148-025-01844-w.
4
miR-3188 inhibits hepatitis B virus transcription by targeting Bcl-2.miR-3188 通过靶向 Bcl-2 抑制乙型肝炎病毒转录。
Arch Virol. 2024 Apr 2;169(5):88. doi: 10.1007/s00705-024-05992-x.
5
The roles and molecular mechanisms of non-coding RNA in cancer metabolic reprogramming.非编码RNA在癌症代谢重编程中的作用及分子机制。
Cancer Cell Int. 2024 Jan 18;24(1):37. doi: 10.1186/s12935-023-03186-0.
6
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Heliyon. 2023 Dec 10;10(1):e23533. doi: 10.1016/j.heliyon.2023.e23533. eCollection 2024 Jan 15.
7
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8
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10
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