Department of Organic Chemistry, Faculty of Science, The University of Yaounde I, Yaounde, Cameroon.
Department of Refining and Petrochemistry, National Advanced School of Mines and Petroleum Industries, The University of Maroua, Kaele, Cameroon.
Nat Prod Res. 2024 Apr;38(8):1294-1301. doi: 10.1080/14786419.2022.2139697. Epub 2022 Oct 29.
A phytochemical study was carried out on stem bark of F. Hoffm., a medicinal plant belonging to the Combretaceae family and used traditionally in the treatment of various ailments. Column chromatography separation on silica gel of the crude methanol extract from stem barks of led to the isolation of a new pentacyclic triterpene acid, with a 3,6-epoxide bridge and trivially named as fragransinic acid (1), along with four known compounds: betulin (2), betulinic acid (3), bellericagenin B (4) and a mixture of -sitosterol (5) and stigmasterol (6). Structures were elucidated by extensive spectroscopic analyses including 1D and 2D NMR, mass spectrometry as well as by comparison with literature data. The above compounds were isolated for the first time from . Implications for chemosystematics and traditional medicine were briefly discussed.
进行了 F. Hoffm. 茎皮的植物化学研究，F. Hoffm. 是卫矛科的一种药用植物，传统上用于治疗各种疾病。硅胶柱层析分离茎皮的粗甲醇提取物得到一种新的五环三萜酸，具有 3,6-环氧桥，俗名 fragransinic 酸（1），以及四种已知化合物：白桦脂醇（2）、白桦脂酸（3）、贝叶瑞林 B（4）和 -谷甾醇（5）和豆甾醇（6）的混合物。通过广泛的光谱分析，包括 1D 和 2D NMR、质谱以及与文献数据的比较，确定了结构。上述化合物首次从 中分离得到。简要讨论了它们在化学系统学和传统医学中的意义。
