Bisoli Eder, Garcez Walmir Silva, Hamerski Lidilhone, Tieppo Caroline, Garcez Fernanda Rodrigues
Departamento de Química, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil, 79070-900.
Molecules. 2008 Nov 1;13(11):2717-28. doi: 10.3390/molecules13112717.
Two new triterpene glucosides, beta-D-glucopyranosyl 2alpha,3beta,24-trihydroxyolean- 12-en-28-oate and beta-D-glucopyranosyl 2alpha,3beta,23,24-tetrahydroxyurs-12-en-28-oate, in addition to nine known compounds belonging to three different triterpene classes (oleanane-, ursane- and lupane-type) have been isolated from the stems of a specimen of Combretum laxum growing in the "Pantanal" of the central-western region of Brazil. Among the known triterpenes, beta-D-glucopyranosyl 2alpha,3beta,6beta-trihydroxyolean-12-en-28-oate is reported for the first time in the Combretaceae, while bellericoside and asiatic acid are described for the first time in the genus Combretum. The structures of the isolated compounds have been established on the basis of spectral techniques (1D-, 2D-NMR and MS). Their in vitro antifungal activities against standard strains of Candida albicans, C. krusei and Cryptococcus neoformans were also evaluated in this work.
从生长在巴西中西部地区“潘塔纳尔湿地”的一种疏花风车子标本的茎中，分离出了两种新的三萜糖苷，即β - D - 吡喃葡萄糖基2α,3β,24 - 三羟基齐墩果 - 12 - 烯 - 28 - 酸酯和β - D - 吡喃葡萄糖基2α,3β,23,24 - 四羟基乌苏 - 12 - 烯 - 28 - 酸酯，此外还有九种属于三种不同三萜类（齐墩果烷型、乌苏烷型和羽扇豆烷型）的已知化合物。在已知的三萜类化合物中，β - D - 吡喃葡萄糖基2α,3β,6β - 三羟基齐墩果 - 12 - 烯 - 28 - 酸酯首次在使君子科中被报道，而信筒子苷和积雪草苷首次在风车子属中被描述。分离得到的化合物的结构是基于光谱技术（一维、二维核磁共振和质谱）确定的。在这项工作中还评估了它们对白色念珠菌、克柔念珠菌和新型隐球菌标准菌株的体外抗真菌活性。
