Ranga V, Kleinerman J
Arch Pathol Lab Med. 1978 Dec;102(12):609-17.
During the last two decades, great strides have been made in our understanding of the functional aspects of airflow in the periphery of the lung. It seems that the small airways are the important site of obstruction in a variety of chronic respiratory disorders associated with airflow obstruction. This review deals with the anatomic and functional aspects of small airways in normal and diseased lungs. In particular, the basis of obstruction or narrowing that is not dependent on intrinsic airway lesion is reviewed. The variety of pathologic changes in small airways observed in these diseases are outlined along with physiologic tests that are currently used to detect dysfunction at a stage long before they produce symptoms or alter standard tests of lung function.
在过去二十年里，我们对肺外周气流功能方面的理解取得了巨大进展。似乎小气道是与气流受限相关的多种慢性呼吸系统疾病中气流受限的重要部位。本综述探讨了正常和患病肺中小气道的解剖和功能方面。特别是，对不依赖于气道固有病变的阻塞或狭窄的基础进行了综述。概述了在这些疾病中观察到的小气道的各种病理变化，以及目前用于在症状出现或肺功能标准测试改变之前很久的阶段检测功能障碍的生理测试。
