Paediatric Dentistry Unit, School of Dental Sciences, Universiti Sains Malaysia, Health Campus, 16150, Kubang Kerian, Kelantan, Malaysia.
Paedodontics Department, Rashid Latif Dental College, Lahore, 54600, Pakistan.
Odontology. 2023 Jul;111(3):531-540. doi: 10.1007/s10266-022-00762-0. Epub 2022 Oct 30.
MicroRNAs (miRNAs) are short, 19-23 nucleotide non-coding RNA molecules that regulate gene expression by silencing or degrading the target mRNA gene. Since their discovery in the nineties of the last century, they have emerged as key inflammatory regulators. Inflammation induces the synthesis of various miRNAs that modulate the expression of multiple molecules involved in orchestrating the inflammatory response. This review aims to provide an insight into the role of miRNAs as potential biomarkers, mediators, and potential therapeutic targets of dental pulp inflammation. A literature search was conducted using the keywords; biogenesis of microRNA, human dental pulp cells, pulpitis, and inflammation in PubMed and Scopus index databases for all the published articles dealing with the role of miRNAs in pulp inflammation in the last 10 years. According to the literature, there is a clear correlation between miRNAs and several physiological events, as well as their role as mediators of innate immune response and inflammation in dental pulp cells. Our narrative review stipulates that numerous miRNAs play a key role in modulating inflammation, delaying or enhancing cell repair, cell differentiation, and survival in dental pulp diseases. However, further studies are required for the validation of miRNAs as reliable biomarkers in dental pulp pathology and their targeted therapy.
微小 RNA（miRNAs）是长度为 19-23 个核苷酸的非编码 RNA 分子，通过沉默或降解靶 mRNA 基因来调节基因表达。自上个世纪九十年代发现以来，它们已成为关键的炎症调节因子。炎症诱导各种 miRNAs 的合成，这些 miRNAs 调节参与炎症反应调控的多种分子的表达。本综述旨在深入了解 miRNAs 作为牙髓炎症的潜在生物标志物、介质和潜在治疗靶点的作用。使用关键词“miRNA 的生物发生、人牙髓细胞、牙髓炎和炎症”在 PubMed 和 Scopus 索引数据库中进行了文献检索，以获取过去 10 年中所有涉及 miRNAs 在牙髓炎症中作用的已发表文章。根据文献，miRNAs 与许多生理事件之间存在明显的相关性，并且它们作为先天免疫反应和牙髓细胞炎症的介质发挥作用。我们的叙述性综述规定，许多 miRNAs 在调节炎症、延迟或增强细胞修复、细胞分化和牙髓疾病中的细胞存活方面发挥关键作用。然而，需要进一步的研究来验证 miRNAs 作为牙髓病理学中可靠生物标志物及其靶向治疗的作用。
