Fuchen-Ramos Dulce Martha, Leija-Montoya Ana Gabriela, González-Ramírez Javier, Isiordia-Espinoza Mario, García-Arévalo Fernando, Pitones-Rubio Viviana, Olvera-Sandoval Carlos, Mateos-Corral Isis, Serafín-Higuera Nicolás
Facultad de Odontología Mexicali, Centro de Ciencias de la Salud Mexicali, Universidad Autónoma de Baja California, Zotoluca s/n, Fracc. Calafia, Mexicali 21040, BC, Mexico.
Facultad de Medicina Mexicali, Universidad Autónoma de Baja California, Centro Cívico, Mexicali 21000, BC, Mexico.
Int J Mol Sci. 2024 Dec 19;25(24):13603. doi: 10.3390/ijms252413603.
Pulpitis, an inflammation of the dental pulp, is generated by bacterial invasion through different ways as caries. In the establishment and development of this disease, different biological processes are involved. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are transcripts with regulatory capacity participating in different biological functions and have been implicated in different diseases. The aim of this narrative review is to critically analyze available evidence on the biological role of lncRNAs and circRNAs in pulpitis and discuss possible new research prospects. LncRNAs and circRNAs involved in pulpitis were explored, addressing their expression, molecular mechanisms, targets and biological effects studied in animal and in vitro models, as well as in studies in human patients. LncRNAs and circRNAs are emerging as key regulators of diverse biological functions in pulpitis including apoptosis, proliferation, differentiation, oxidative stress, autophagy, ferroptosis, inflammation and immune response. The molecular mechanisms performed by these non-coding RNAs (ncRNAs) involved interactions with miRNAs and the formation of regulatory networks in the context of pulpitis. Further studies more deeply analyzing the participation of lncRNAs and circRNAs in pulpitis will reveal the potential applications of these ncRNAs as biomarkers or their use in therapeutic strategies in pulp inflammation.
牙髓炎是牙髓的一种炎症，由细菌通过龋齿等不同途径侵入引发。在这种疾病的发生和发展过程中，涉及不同的生物学过程。长链非编码RNA（lncRNAs）和环状RNA（circRNAs）是具有调控能力的转录本，参与不同的生物学功能，并与多种疾病有关。本叙述性综述的目的是批判性地分析关于lncRNAs和circRNAs在牙髓炎中的生物学作用的现有证据，并讨论可能的新研究前景。我们探讨了参与牙髓炎的lncRNAs和circRNAs，涉及它们在动物和体外模型以及人类患者研究中的表达、分子机制、靶点和生物学效应。lncRNAs和circRNAs正在成为牙髓炎中多种生物学功能的关键调节因子，包括细胞凋亡、增殖、分化、氧化应激、自噬、铁死亡、炎症和免疫反应。这些非编码RNA（ncRNAs）所执行的分子机制涉及与微小RNA（miRNAs）的相互作用以及在牙髓炎背景下形成调控网络。进一步深入分析lncRNAs和circRNAs在牙髓炎中的参与情况的研究，将揭示这些ncRNAs作为生物标志物的潜在应用，或它们在牙髓炎症治疗策略中的应用。
