Johnson C C, Annegers J F, Frankowski R F, Spitz M R, Buffler P A
Am J Epidemiol. 1987 Oct;126(4):605-13. doi: 10.1093/oxfordjournals.aje.a114700.
Paternal occupational exposures to hydrocarbons have been associated with childhood nervous system cancer, but study results have not been consistent. This population-based case-control study was designed to examine this association using a large sample size to increase the precision of risk estimates. The birth certificates of 499 children who died in Texas from intracranial and spinal cord tumors were compared with 998 control certificates randomly selected from all Texas live births. Information on parental job title and industry at the time of birth was obtained from the birth certificates. No significant associations were identified for the dichotomized variable of all hydrocarbon-related occupations combined, as variously defined in previous studies, or for most of the specific jobs affiliated with exposures to hydrocarbons. Significant, relatively stable odds ratios (OR) were found for printers and graphics arts workers (OR = 4.5; 95% confidence interval (CI) = 1.4-14.7) and chemical and petroleum workers with high exposure levels (OR = 3.0; CI = 1.1-8.5). A discussion of the biases involved in this type of study design is presented.
父亲职业性接触碳氢化合物与儿童神经系统癌症有关，但研究结果并不一致。这项基于人群的病例对照研究旨在通过使用大样本量来提高风险估计的精度，从而检验这种关联。将得克萨斯州499名死于颅内和脊髓肿瘤的儿童的出生证明与从得克萨斯州所有活产中随机抽取的998份对照证明进行比较。从出生证明中获取了父母在孩子出生时的职业头衔和行业信息。对于先前研究中不同定义的所有与碳氢化合物相关职业的二分变量，或与接触碳氢化合物相关的大多数特定工作，均未发现显著关联。对于印刷工人和平面艺术工作者（优势比=4.5；95%置信区间=1.4-14.7）以及高暴露水平的化学和石油工人（优势比=3.0；置信区间=1.1-8.5），发现了显著且相对稳定的优势比。本文对这类研究设计中涉及的偏倚进行了讨论。
