Zack M, Cannon S, Loyd D, Heath C W, Falletta J M, Jones B, Housworth J, Crowley S
Am J Epidemiol. 1980 Mar;111(3):329-36. doi: 10.1093/oxfordjournals.aje.a112904.
Recent animal and human studies suggest that prenatal exposure to carcinogens may increase the risk of childhood malignancy. The Texas Childhood Cancer Study (1976-1977) was designed to test the hypothesis that parental exposure to hydrocarbon-related occupations or industries increases this risk. The study subjects, parents of children with and without cancer, were questioned about their job histories. Parents of 296 children with cancer were not exposed to hydrocarbon-related occupations or industries more often than the uncles and aunts of these children, the parents of neighborhood children, or the parents of 283 children without cancer. During the year before birth, odds ratios for fathers of children seen at a hematology clinic with cancer relative to the uncles of these children (0.93), the fathers of neighborhood children (1.33), and the fathers of children seen at the clinic without cancer (0.50) were not statistically significantly different from 1.00 (p greater than 0.05). This lack of association persisted for the year after birth, the year before diagnosis, and the interval from the year before birth to the year of diagnosis; for different diagnoses; for different ages at diagnosis; and for the industries and occupations of female as well as male parents.
近期的动物和人体研究表明，产前接触致癌物可能会增加儿童患恶性肿瘤的风险。德克萨斯儿童癌症研究（1976 - 1977年）旨在检验这样一种假设，即父母接触与碳氢化合物相关的职业或行业会增加这种风险。研究对象为患癌儿童和未患癌儿童的父母，研究人员询问了他们的工作经历。与这些患癌儿童的叔叔阿姨、邻居家孩子的父母或283名未患癌儿童的父母相比，296名患癌儿童的父母接触与碳氢化合物相关职业或行业的情况并没有更频繁。在孩子出生前一年，在血液学诊所就诊的患癌儿童的父亲与这些孩子的叔叔（比值比为0.93）、邻居家孩子的父亲（比值比为1.33）以及在诊所就诊的未患癌儿童的父亲（比值比为0.50）相比，与1.00没有统计学上的显著差异（p大于0.05）。这种缺乏关联的情况在孩子出生后一年、诊断前一年以及从出生前一年到诊断当年的时间段内均持续存在；在不同诊断中；在不同诊断年龄中；以及在女性和男性父母的行业和职业方面均如此。
