Buksh Omar, Almalki Abdullah M, Khogeer Ahmed, Al-Maghrabi Jaudah, Alakraa Mahmoud
Department of Urology, King Faisal Specialist Hospital and Research Centre, Jeddah, SAU.
Department of Pathology, Faculty of Medicine, King Abdulaziz University, Jeddah, SAU.
Cureus. 2022 Sep 25;14(9):e29556. doi: 10.7759/cureus.29556. eCollection 2022 Sep.
Inflammatory myofibroblastic tumor (IMT) is a rare type of tumor composed mainly of fibroblastic and myofibroblastic spindle cells, with an inflammatory infiltrate of lymphocytes, plasma cells, and eosinophils. IMT may arise from different organs and sites, but it is infrequent to arise from the urinary bladder and usually manifests as hematuria. We report a case of a 24-year-old pregnant woman who presented to our hospital with gross hematuria. After further workup, we concluded that she had this extremely rare tumor, which was resected eventually with a partial cystectomy. Although the diagnosis of these kinds of tumors is usually made by anaplastic lymphoma kinase (ALK) using immunohistochemistry and detecting ALK gene translocation using fluorescence in situ hybridization (FISH), they were negative in our study; hence, we relied mainly on the morphological features of the tumor for the diagnosis.
炎性肌成纤维细胞瘤（IMT）是一种罕见的肿瘤，主要由成纤维细胞和肌成纤维细胞梭形细胞组成，并伴有淋巴细胞、浆细胞和嗜酸性粒细胞的炎性浸润。IMT可起源于不同器官和部位，但起源于膀胱者罕见，通常表现为血尿。我们报告一例24岁的孕妇，她因肉眼血尿前来我院就诊。经过进一步检查，我们诊断她患有这种极其罕见的肿瘤，最终行部分膀胱切除术将其切除。虽然这类肿瘤的诊断通常通过免疫组织化学检测间变性淋巴瘤激酶（ALK）以及使用荧光原位杂交（FISH）检测ALK基因易位来进行，但在我们的研究中这些检测结果均为阴性；因此，我们主要依靠肿瘤的形态学特征进行诊断。
