Sarmiento-Andrade Yoredy, Suárez Rosario, Quintero Beatriz, Garrochamba Kleber, Chapela Sebastián Pablo
School of Medicine, Universidad Técnica Particular de Loja, Loja, Ecuador.
Department of Health Sciences, Universidad Técnica Particular de Loja, Loja, Ecuador.
Front Nutr. 2022 Oct 14;9:1018212. doi: 10.3389/fnut.2022.1018212. eCollection 2022.
Obesity is a pathology whose incidence is increasing throughout the world. There are many pathologies associated with obesity. In recent years, the influence of the microbiota on both health and pathological states has been known. There is growing information related to changes in the microbiome and obesity, as well as its associated pathologies. Changes associated with age, exercise, and weight changes have been described. In addition, metabolic changes associated with the microbiota, bariatric surgery, and fecal matter transplantation are described. In this review, we summarize the biology and physiology of microbiota in obese patients, its role in the pathophysiology of several disorders associated, and the emerging therapeutic applications of prebiotics, probiotics, and fecal microbiota transplantation.
肥胖是一种在全球发病率不断上升的病理状态。有许多与肥胖相关的病症。近年来,微生物群对健康和病理状态的影响已为人所知。关于微生物组变化与肥胖及其相关病症的信息越来越多。已经描述了与年龄、运动和体重变化相关联的变化。此外,还描述了与微生物群、减肥手术和粪便移植相关的代谢变化。在本综述中,我们总结了肥胖患者微生物群的生物学和生理学、其在几种相关疾病病理生理学中的作用,以及益生元、益生菌和粪便微生物群移植的新兴治疗应用。