Wang Feifei, He Ting, Wang Guoliang, Han Tuo, Yao Zhongqiang
Department of Oncology, The 3201 Hospital Affiliated to Medical Department of Xi'an Jiaotong University, Hanzhong, Shaanxi, China.
Department of Orthopedics, Second Affiliated Hospital, Air Force Medical University, Xi'an, Shaanxi, China.
Front Nutr. 2022 Oct 14;9:1004179. doi: 10.3389/fnut.2022.1004179. eCollection 2022.
Insulin resistance (IR) is closely related to non-small-cell lung cancer (NSCLC) risk. Recently, triglyceride glucose-body mass index (TyG-BMI) has been recognized as one of the simple indexes of insulin resistance (IR). However, there are limited data on the relationship between TyG-BMI and NSCLC. Here, we investigated the association of TyG-BMI with NSCLC risk in Chinese adults.
This study consisted of 477 NSCLC cases and 954 healthy subjects. All participants were enrolled from 3201 Hospital affiliated to the Medical Department of Xi'an Jiaotong University. TyG-BMI was calculated based on the values of fasting blood glucose, triglyceride, and BMI. The association of TyG-BMI with NSCLC risk was estimated by logistic regression analysis.
The mean value of TyG-BMI was statistically increased in patients with NSCLC compared to the control group (201.11 ± 28.18 vs. 174 ± 23.78, < 0.01). There was a significant positive association between TyG-BMI and NSCLC ( = 1.014; 95% CI 1.007-1.021; < 0.001) after controlling for confounding factors. Moreover, the prevalence of NSCLC was significantly elevated in participants in the high TyG-BMI tertiles than those in the intermediate and low TyG-BMI tertiles (60.46% vs. 12.61% vs. 26.83%, < 0.01). Importantly, TyG-BMI achieved a significant diagnostic accuracy for NSCLC, with an AUC (area under the curve) of 0.769 and a cutoff value of 184.87.
The findings suggest that TyG-BMI is a useful tool for assessing NSCLC risk. Thus, it is essential to follow up on high TyG-BMI, and lifestyle modification is needed to prevent NSCLC in people with high TyG-BMI.
胰岛素抵抗（IR）与非小细胞肺癌（NSCLC）风险密切相关。近来，甘油三酯葡萄糖-体重指数（TyG-BMI）已被视为胰岛素抵抗（IR）的简单指标之一。然而，关于TyG-BMI与NSCLC之间关系的数据有限。在此，我们调查了中国成年人中TyG-BMI与NSCLC风险的关联。
本研究包括477例NSCLC病例和954名健康受试者。所有参与者均来自西安交通大学医学部附属3201医院。TyG-BMI根据空腹血糖、甘油三酯和BMI值计算得出。通过逻辑回归分析评估TyG-BMI与NSCLC风险的关联。
与对照组相比，NSCLC患者的TyG-BMI平均值在统计学上显著升高（201.11±28.18 vs. 174±23.78，P<0.01）。在控制混杂因素后，TyG-BMI与NSCLC之间存在显著正相关（OR = 1.014；95% CI 1.007 - 1.021；P<0.001）。此外，高TyG-BMI三分位数组参与者的NSCLC患病率显著高于中、低TyG-BMI三分位数组（60.46% vs. 12.61% vs. 26.83%，P<0.01）。重要的是，TyG-BMI对NSCLC具有显著的诊断准确性，曲线下面积（AUC）为0.769，截断值为184.87。
研究结果表明，TyG-BMI是评估NSCLC风险的有用工具。因此，对高TyG-BMI者进行随访至关重要，并且需要通过改变生活方式来预防高TyG-BMI人群患NSCLC。
