甘油三酯-葡萄糖体重指数与尿失禁的关系：来自 2001 至 2018 年全国健康和营养调查（NHANES）的横断面研究。

Association between triglyceride glucose body mass index and urinary incontinence: a cross-sectional study from the National Health and Nutrition Examination Survey (NHANES) 2001 to 2018.

机构信息

Department of Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, China.

Department of Hand & Foot Surgery, Hengyang Medical School, The Affiliated Nanhua Hospital, University of South China, Hengyang, 421002, China.

出版信息

Lipids Health Dis. 2024 Sep 20;23(1):304. doi: 10.1186/s12944-024-02306-7.

DOI:10.1186/s12944-024-02306-7

PMID:39304881

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11415990/

Abstract

BACKGROUND

Urinary incontinence (UI) is a prevalent, health-threatening condition that causes isolation and psychological strain, leading to significant personal distress. The connection between the triglyceride glucose body mass index (TyG-BMI) and UI remains elusive. The purpose of the current research was to investigate any possible relationships between raised TyG-BMI levels and a higher likelihood of UI.

METHODS

For a thorough examination, adults 20 years and older with UI were included in cross-sectional research using the data obtained from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2018. Our investigation centred on three of the significant varieties of UI: Urgent Urinary Incontinence (UUI), Mixed Urinary Incontinence (MUI), and Stress Urinary Incontinence (SUI), employing weighted multivariate logistic regression models for an in-depth evaluation. The TyG-BMI, a possible biomarker, was arranged in increasing order among participants and then assessed with a trend test (P for trend). Moreover, this investigation delved into the non-linear relationships using advanced smoothed curve fitting techniques. Meticulous subgroup analyses were executed to verify the uniformity of the UI and TyG-BMI relationship across diverse demographic groups.

RESULTS

A thorough investigation was conducted with 18,751 subjects to analyze the prevalence and types of UI, showing that 23.59% of individuals suffered from SUI, 19.42% from UUI, and 9.32% from MUI. Considering all possible confounding variables, Multivariate logistic regression analysis showed a substantial relationship between elevated TyG-BMI values and a greater likelihood across all UI categories. Specifically, stratifying the TyG-BMI into quartiles revealed a pronounced positive correlation in the top quartile relative to the bottom, reflected in increased odds ratios for SUI, UUI, and MUI (SUI: OR = 2.36, 95% CI 2.03-2.78, P < 0.0001; UUI: OR = 1.86, 95% CI 1.65-2.09, P < 0.0001; MUI: OR = 2.07, 95% CI 1.71-2.51, P < 0.0001).

CONCLUSIONS

Among US adults, an association has been observed wherein increased TyG-BMI values correlate with a higher chance of UI. This suggests that TyG-BMI might be a helpful marker for identifying individuals at risk of UI, providing novel insights into its assessment and management.

摘要

背景

尿失禁（UI）是一种普遍存在且威胁健康的疾病，会导致隔离和心理压力，给个人带来严重的痛苦。甘油三酯-葡萄糖体重指数（TyG-BMI）与 UI 之间的联系仍不清楚。本研究的目的是调查 TyG-BMI 水平升高与 UI 发生概率之间是否存在任何关联。

方法

采用横断面研究，使用 2001 年至 2018 年国家健康和营养检查调查（NHANES）的数据，纳入患有 UI 的 20 岁及以上成年人。我们的研究集中在三种主要的 UI 类型上：急迫性尿失禁（UUI）、混合性尿失禁（MUI）和压力性尿失禁（SUI），采用加权多变量逻辑回归模型进行深入评估。TyG-BMI 是一种可能的生物标志物，我们对参与者进行了升序排列，然后使用趋势检验（趋势检验 P 值，P for trend）进行评估。此外，我们还使用先进的平滑曲线拟合技术研究了非线性关系。进行了细致的亚组分析，以验证 UI 和 TyG-BMI 关系在不同人群中的一致性。

结果

对 18751 名受试者进行了全面调查，以分析 UI 的患病率和类型，结果显示 23.59%的患者患有 SUI，19.42%的患者患有 UUI，9.32%的患者患有 MUI。考虑到所有可能的混杂变量，多变量逻辑回归分析显示，TyG-BMI 升高与所有 UI 类型的发生概率之间存在显著关联。具体而言，将 TyG-BMI 分为四分位数后，与最低四分位数相比，最高四分位数的相关性明显呈正相关，反映了 SUI、UUI 和 MUI 的优势比增加（SUI：比值比=2.36，95%置信区间 2.03-2.78，P<0.0001；UUI：比值比=1.86，95%置信区间 1.65-2.09，P<0.0001；MUI：比值比=2.07，95%置信区间 1.71-2.51，P<0.0001）。