Yan Xin, Gao Yujuan, Tong Jingzhi, Tian Mi, Dai Jinghong, Zhuang Yi
Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Front Oncol. 2021 Mar 11;11:585388. doi: 10.3389/fonc.2021.585388. eCollection 2021.
Numerous studies showed that insulin resistance (IR) was associated with cancer risk. However, few studies investigated the relationship between IR and non-small cell lung cancer (NSCLC). The aim of this study is to explore the association of triglyceride glucose (TyG) index, a simple surrogate marker of IR, with NSCLC risk.
791 histologically confirmed NSCLC cases and 787 controls were enrolled in the present study. Fasting blood glucose and triglyceride were measured. The TyG index was calculated as ln [fasting triglycerides (mg/dl) ×fasting glucose (mg/dl)/2]. Logistic regression analysis was performed to estimate the relationship between NSCLC risk and the TyG index.
The TyG index was significantly higher in patients with NSCLC than that in controls (8.42 ± 0.55 8.00 ± 0.45, < 0.01). Logistic regression analysis showed that the TyG index ( = 3.651, 95% 2.461-5.417, < 0.001) was independently associated with NSCLC risk after adjusting for conventional risk factors. In addition, a continuous rise in the incidence of NSCLC was observed along the tertiles of the TyG index (29.4 53.8 67.2%, < 0.001). However, there were no differences of the TyG index in different pathological or TNM stages. In receiver operating characteristic (ROC) curve analysis, the optimal cut-off level for the TyG index to predict incident NSCLC was 8.18, and the area under the ROC curve (AUROC) was 0.713(95% 0.688-0.738).
The TyG index is significantly correlated with NSCLC risk, and it may be suitable as a predictor for NSCLC.
大量研究表明胰岛素抵抗（IR）与癌症风险相关。然而，很少有研究调查IR与非小细胞肺癌（NSCLC）之间的关系。本研究的目的是探讨甘油三酯葡萄糖（TyG）指数（一种简单的IR替代标志物）与NSCLC风险之间的关联。
本研究纳入了791例经组织学确诊的NSCLC病例和787例对照。测量空腹血糖和甘油三酯。TyG指数计算为ln[空腹甘油三酯（mg/dl）×空腹血糖（mg/dl）/2]。进行逻辑回归分析以评估NSCLC风险与TyG指数之间的关系。
NSCLC患者的TyG指数显著高于对照组（8.42±0.55对8.00±0.45，P<0.01）。逻辑回归分析显示，在调整传统风险因素后，TyG指数（β=3.651，95%CI 2.461-5.417，P<0.001）与NSCLC风险独立相关。此外，随着TyG指数三分位数的升高，NSCLC发病率持续上升（29.4%、53.8%、67.2%，P<0.001）。然而，不同病理或TNM分期的TyG指数没有差异。在受试者工作特征（ROC）曲线分析中，TyG指数预测新发NSCLC的最佳截断水平为8.18，ROC曲线下面积（AUROC）为0.713（95%CI 0.688-0.738）。
TyG指数与NSCLC风险显著相关，可能适合作为NSCLC的预测指标。
