Department of Anesthesiology, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, China.
Department of Cardiology, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, China.
Int J Med Sci. 2022 Sep 28;19(12):1753-1761. doi: 10.7150/ijms.73740. eCollection 2022.
The nonreceptor tyrosine kinase c-Abl is inactive under normal conditions. Upon activation, c-Abl regulates signaling pathways related to cytoskeletal reorganization. It plays a vital role in modulating cell protrusion, cell migration, morphogenesis, adhesion, endocytosis and phagocytosis. A large number of studies have also found that abnormally activated c-Abl plays an important role in a variety of pathologies, including various inflammatory diseases and neurodegenerative diseases. c-Abl also plays a crucial role in neurodevelopment and neurodegenerative diseases, mainly through mechanisms such as neuroinflammation, oxidative stress (OS), and Tau protein phosphorylation. Inhibiting expression or activity of this kinase has certain neuroprotective and anti-inflammatory effects and can also improve cognition and behavior. Blockers of this kinase may have good preventive and treatment effects on neurodegenerative diseases. Cognitive dysfunction after anesthesia is also closely related to the abovementioned mechanisms. We infer that alterations in the expression and activity of c-Abl may underlie postoperative cognitive dysfunction (POCD). This article summarizes the current understanding and research progress on the mechanisms by which c-Abl may be related to postoperative neurodegeneration.
非受体酪氨酸激酶 c-Abl 在正常情况下处于非激活状态。激活后，c-Abl 调节与细胞骨架重排相关的信号通路。它在调节细胞突出、细胞迁移、形态发生、黏附、内吞和吞噬作用方面起着至关重要的作用。大量研究还发现，异常激活的 c-Abl 在多种病理中起着重要作用，包括各种炎症性疾病和神经退行性疾病。c-Abl 还在神经发育和神经退行性疾病中起着关键作用，主要通过神经炎症、氧化应激（OS）和 Tau 蛋白磷酸化等机制。抑制该激酶的表达或活性具有一定的神经保护和抗炎作用，还可以改善认知和行为。该激酶的抑制剂可能对神经退行性疾病具有良好的预防和治疗作用。麻醉后认知功能障碍也与上述机制密切相关。我们推断，c-Abl 的表达和活性的改变可能是术后认知功能障碍（POCD）的基础。本文总结了目前对 c-Abl 与术后神经退行性变相关机制的认识和研究进展。
