Department of Pharmacy, National Center for Geriatrics and Gerontology, Obu, Japan.
Department of Pharmacy, National Hospital Organization Sakakibara Hospital, Tsu, Japan.
J Int Med Res. 2022 Oct;50(10):3000605221130716. doi: 10.1177/03000605221130716.
To investigate the effects of discontinuing antihypertensive drugs on the characteristics of patients with frailty syndrome.
This prospective pilot study was conducted between March 2016 and July 2019. Among patients who visited the frailty clinic within this period, outpatients who received antihypertensive drugs at their first visit and were followed-up for about 1 year were enrolled. Participants who discontinued or continued antihypertensive drugs during 1 year of follow-up were classified into a discontinuation group or continuation group, respectively. Each domain in the Kihon checklist (KCL), fall risk score, short physical performance battery (SPPB) score, and skeletal muscle index (SMI) were assessed at the first visit and 1-year follow-up assessment, and were compared between the two groups.
Among 498 patients who attended the frailty clinic, 78 were enrolled (discontinuation group, = 19; continuation group, = 59). At the first visit, SMI scores were significantly higher in the discontinuation versus continuation group. At the 1-year assessment, physical strength in the KCL for the discontinuation group and various SPPB scores for both groups were significantly improved, and the fall risk score was improved in the continuation group.
Discontinuation of antihypertensive drugs may positively affect physical performance.
探讨停止降压药物对衰弱综合征患者特征的影响。
本前瞻性初步研究于 2016 年 3 月至 2019 年 7 月进行。在该期间内就诊于衰弱门诊的患者中，招募了首次就诊时正在服用降压药物且随访约 1 年的门诊患者。在 1 年随访期间停止或继续使用降压药物的患者分别归入停药组或继续用药组。在首次就诊和 1 年随访评估时，评估了 Kihon 检查表（KCL）的每个领域、跌倒风险评分、简短体能表现电池（SPPB）评分和骨骼肌指数（SMI），并比较了两组之间的差异。
在就诊于衰弱门诊的 498 例患者中，纳入了 78 例患者（停药组，n=19；继续用药组，n=59）。在首次就诊时，停药组的 SMI 评分明显高于继续用药组。在 1 年评估时，停药组的 KCL 体力明显改善，两组的 SPPB 评分均有所提高，继续用药组的跌倒风险评分也有所改善。
停止使用降压药物可能对身体机能产生积极影响。
