Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD, USA.
Department of Social and Behavioral Science, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
J Natl Cancer Inst. 2023 Feb 8;115(2):131-138. doi: 10.1093/jnci/djac198.
The National Cancer Institute's Implementation Science Centers in Cancer Control (ISC3) Network represents a large-scale initiative to create an infrastructure to support and enable the efficient, effective, and equitable translation of approaches and evidence-based treatments to reduce cancer risk and improve outcomes. This Cancer MoonshotSM-funded ISC3 Network consists of 7 P50 Centers that support and advance the rapid development, testing, and refinement of innovative approaches to implement a range of evidence-based cancer control interventions. The Centers were designed to have research-practice partnerships at their core and to create the opportunity for a series of pilot studies that could explore new and sometimes risky ideas and embed in their infrastructure a 2-way engagement and collaboration essential to stimulating lasting change. ISC3 also seeks to enhance capacity of researchers, practitioners, and communities to apply implementation science approaches, methods, and measures. The Organizing Framework that guides the work of ISC3 highlights a collective set of 3 core areas of collaboration within and among Centers, including to 1) assess and incorporate dynamic, multilevel context; 2) develop and conduct rapid and responsive pilot and methods studies; and 3) build capacity for knowledge development and exchange. Core operating principles that undergird the Framework include open collaboration, consideration of the dynamic context, and engagement of multiple implementation partners to advance pragmatic methods and health equity and facilitate leadership and capacity building across implementation science and cancer control.
美国国家癌症研究所的癌症控制实施科学中心（ISC3）网络代表了一项大规模的计划，旨在建立一个基础设施，以支持和促进将方法和循证治疗转化为降低癌症风险和改善结果的效率、效果和公平性。这个由“癌症登月计划”资助的 ISC3 网络由 7 个 P50 中心组成，这些中心支持和推进创新方法的快速开发、测试和完善，以实施一系列循证癌症控制干预措施。这些中心的设计以研究-实践伙伴关系为核心，并为一系列试点研究创造机会，这些研究可以探索新的、有时是有风险的想法，并在其基础设施中嵌入双向参与和合作，这对激发持久变革至关重要。ISC3 还旨在增强研究人员、从业人员和社区应用实施科学方法、方法和措施的能力。指导 ISC3 工作的组织框架强调了中心内部和中心之间合作的三个核心领域，包括 1）评估和纳入动态、多层次的背景；2）开发和进行快速和响应式试点和方法研究；3）为知识发展和交流建立能力。支撑该框架的核心运营原则包括开放协作、考虑动态背景以及让多个实施合作伙伴参与，以推进实用方法和健康公平，并促进实施科学和癌症控制领域的领导力和能力建设。
