Lewis Cara C, Hannon Peggy A, Klasnja Predrag, Baldwin Laura-Mae, Hawkes Rene, Blackmer Janell, Johnson Ashley
Kaiser Permanente Washington Health Research Institute, 1730 Minor Avenue, Suite 1600, Seattle, WA, 98101, USA.
Department of Health Services, University of Washington, Seattle, WA, USA.
Implement Sci Commun. 2021 Apr 23;2(1):44. doi: 10.1186/s43058-021-00117-w.
Evidence-based interventions (EBIs) could reduce cervical cancer deaths by 90%, colorectal cancer deaths by 70%, and lung cancer deaths by 95% if widely and effectively implemented in the USA. Yet, EBI implementation, when it occurs, is often suboptimal. This manuscript outlines the protocol for Optimizing Implementation in Cancer Control (OPTICC), a new implementation science center funded as part of the National Cancer Institute Implementation Science Consortium. OPTICC is designed to address three aims. Aim 1 is to develop a research program that supports developing, testing, and refining of innovative, efficient methods for optimizing EBI implementation in cancer control. Aim 2 is to support a diverse implementation laboratory of clinical and community partners to conduct rapid, implementation studies anywhere along the cancer care continuum for a wide range of cancers. Aim 3 is to build implementation science capacity in cancer control by training new investigators, engaging established investigators in cancer-focused implementation science, and contributing to the Implementation Science Consortium in Cancer.
Three cores serve as OPTICC's foundation. The Administrative Core plans coordinates and evaluates the Center's activities and leads its capacity-building efforts. The Implementation Laboratory Core (I-Lab) coordinates a network of diverse clinical and community sites, wherein studies are conducted to optimize EBI implementation, implement cancer control EBIs, and shape the Center's agenda. The Research Program Core conducts innovative implementation studies, measurement and methods studies, and pilot studies that advance the Center's theme. A three-stage approach to optimizing EBI implementation is taken-(I) identify and prioritize determinants, (II) match strategies, and (III) optimize strategies-that is informed by a transdisciplinary team of experts leveraging multiphase optimization strategies and criteria, user-centered design, and agile science.
OPTICC will develop, test, and refine efficient and economical methods for optimizing EBI implementation by building implementation science capacity in cancer researchers through applications with our I-Lab partners. Once refined, OPTICC will disseminate its methods as toolkits accompanied by massive open online courses, and an interactive website, the latter of which seeks to simultaneously accumulate knowledge across OPTICC studies.
如果在美国广泛且有效地实施基于证据的干预措施（EBIs），可将宫颈癌死亡率降低90%，结直肠癌死亡率降低70%，肺癌死亡率降低95%。然而，EBIs的实施即便发生，往往也未达最佳效果。本手稿概述了癌症控制优化实施（OPTICC）方案，这是一个新的实施科学中心，作为国家癌症研究所实施科学联盟的一部分获得资助。OPTICC旨在实现三个目标。目标1是制定一项研究计划，支持开发、测试和完善用于优化癌症控制中EBIs实施的创新、高效方法。目标2是支持一个由临床和社区合作伙伴组成的多元化实施实验室，在癌症护理连续过程中的任何地点针对多种癌症开展快速实施研究。目标3是通过培训新的研究人员、让资深研究人员参与以癌症为重点的实施科学研究以及为癌症实施科学联盟做出贡献，来建设癌症控制方面的实施科学能力。
三个核心构成了OPTICC的基础。行政核心负责规划、协调和评估该中心的活动，并领导其能力建设工作。实施实验室核心（I-Lab）协调一个由不同临床和社区地点组成的网络，在其中开展研究以优化EBIs实施、实施癌症控制EBIs并确定该中心的议程。研究计划核心开展创新实施研究、测量和方法研究以及试点研究，推进该中心的主题。采用一种三阶段方法来优化EBIs实施——（I）识别并确定决定因素的优先级，（II）匹配策略，以及（III）优化策略——这是由一个跨学科专家团队提供信息的，该团队利用多阶段优化策略和标准、以用户为中心的设计以及敏捷科学。
OPTICC将通过与我们的I-Lab合作伙伴合作，在癌症研究人员中建设实施科学能力，从而开发、测试和完善用于优化EBIs实施的高效且经济的方法。一旦完善，OPTICC将把其方法作为工具包进行传播，并辅以大规模开放在线课程和一个交互式网站，后者旨在同时积累OPTICC各项研究的知识。
