中国汉族人群样本中的γ-谷氨酰转肽酶与血小板和γ-谷氨酰转肽酶与淋巴细胞比值。
Gamma-glutamyl transpeptidase to platelet and gamma-glutamyl transpeptidase to lymphocyte ratio in a sample of Chinese Han population.
机构信息
The First Affiliated Hospital, Shantou University Medical College, 515041, Shantou, China.
School of Public Health, Shantou University, 515041, Shantou, China.
出版信息
BMC Gastroenterol. 2022 Oct 31;22(1):442. doi: 10.1186/s12876-022-02509-1.
BACKGROUND
Gamma-glutamyl transpeptidase to platelet ratio (GPR) and gamma-glutamyl transpeptidase to lymphocyte ratio (GLR) are assumed to be prognostic factors in liver fibrosis, cirrhosis and hepatocellular carcinoma. However, the reference values of GPR and GLR were not known.
OBJECTIVES
The study aimed to investigate the reference ranges of GPR and GLR in Chinese Han population in Chaoshan region in South China.
METHODS
A retrospective study was conducted in the First Affiliated Hospital of Shantou University Medical College in South China. 2400 healthy adults aged 20~79 years were included. GPR and GLR were determined.
RESULTS
Of 2400 healthy adults, 1200 men and 1200 women were included. The median GPR and GLR for men were 0.22 and 11.28, for women were 0.18 and 7.86, respectively. The 95% reference range of GPR in normal male and female are 0.090.54 and 0.080.55, GLR are 4.5529.64 and 3.5223.08, respectively. The male had a higher GPR at age 2049 than the female while the GPR at age 6079 was higher in the female than in the male. The GPR was affected by age, decreased with aging in male and increased in female. The GLR was higher in the male than in the female and varied with aging in the female but not in the male.
CONCLUSION
The study provides reference data on GPR and GLR from different age and sex groups in South China. GPR and GLR varied with age and sex.
背景
γ-谷氨酰转肽酶与血小板比值（GPR）和γ-谷氨酰转肽酶与淋巴细胞比值（GLR）被认为是肝纤维化、肝硬化和肝细胞癌的预后因素。然而，GPR 和 GLR 的参考值尚不清楚。
目的
本研究旨在探讨中国华南潮汕地区汉族人群 GPR 和 GLR 的参考范围。
方法
本研究为回顾性研究，在中国华南汕头大学医学院第一附属医院进行。纳入 2400 名年龄在 20~79 岁的健康成年人。测定 GPR 和 GLR。
结果
在 2400 名健康成年人中，包括 1200 名男性和 1200 名女性。男性 GPR 和 GLR 的中位数分别为 0.22 和 11.28，女性分别为 0.18 和 7.86。正常男性和女性 GPR 的 95%参考范围分别为 0.090.54 和 0.080.55，GLR 分别为 4.5529.64 和 3.5223.08。2049 岁的男性 GPR 高于女性，而 6079 岁的女性 GPR 高于男性。GPR 受年龄影响，男性随年龄增长而降低，女性则增加。GLR 男性高于女性，女性随年龄变化，男性则无变化。
结论
本研究提供了来自中国华南不同年龄和性别人群的 GPR 和 GLR 参考数据。GPR 和 GLR 随年龄和性别而变化。
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