Department of Cardiology, the First Affiliated Hospital, Shantou University Medical College, Shantou, 515041, Guangdong, China.
BMC Cardiovasc Disord. 2019 May 27;19(1):125. doi: 10.1186/s12872-019-1110-7.
Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are assumed to be prognostic factors in many diseases such as inflammatory diseases, cardiovascular diseases and cancer. However, NLR and PLR are race specific, it is important to determine the reference values of NLR and PLR in different races. The study aimed to investigate the reference range of NLR and PLR in Chinese Han population from Chaoshan region in South China.
A retrospective study was conducted in the First Affiliated Hospital of Shantou University Medical College in South China. Five thousand healthy adults aged 20-69 years were included. NLR and PLR were determined.
Of 5000 healthy adults, 2500 men and 2500 women were included. The mean NLR and PLR across all ages for men and women were 1.59 ± 0.59, 92.88 ± 28.70, 1.62 ± 0.64 and 108.02 ± 32.99, respectively. The 95% reference range of NLR in normal male and female are 0.432.75 and 0.372.87, PLR are 36.63149.13 and 43.36172.68, respectively. The female had a higher NLR at age 3049 than the male while the NLR at age 6069 was higher in male than in female. The PLR was higher in female than in male.
The study provides reference data on NLR and PLR from different age and sex groups in South China. NLR and PLR varied with age and sex.
中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）被认为是许多疾病的预后因素，如炎症性疾病、心血管疾病和癌症。然而，NLR 和 PLR 是种族特异性的，因此确定不同种族 NLR 和 PLR 的参考值非常重要。本研究旨在探讨中国潮汕地区汉族人群 NLR 和 PLR 的参考范围。
这是一项在中国南方汕头大学医学院第一附属医院进行的回顾性研究。纳入了 5000 名年龄在 20-69 岁的健康成年人。测定 NLR 和 PLR。
在 5000 名健康成年人中，男性 2500 名，女性 2500 名。男女各年龄段的平均 NLR 和 PLR 分别为 1.59±0.59、92.88±28.70、1.62±0.64 和 108.02±32.99。正常男性和女性 NLR 的 95%参考范围分别为 0.432.75 和 0.372.87，PLR 分别为 36.63149.13 和 43.36172.68。女性 3049 岁时 NLR 高于男性，而 6069 岁时男性 NLR 高于女性。PLR 女性高于男性。
本研究提供了中国南方不同年龄和性别组 NLR 和 PLR 的参考数据。NLR 和 PLR 随年龄和性别而变化。
